Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior

Abstract Although biopsies and tumor resection are prognostically beneficial for glioblastomas (GBM), potential negative effects have also been suggested. Here, using retrospective study of patients and intravital imaging of mice, we identify some of these negative aspects, including stimulation of...

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Autores principales:	Maria Alieva, Andreia S. Margarido, Tamara Wieles, Erik R. Abels, Burcin Colak, Carla Boquetale, Herke Jan Noordmans, Tom J. Snijders, Marike L. Broekman, Jacco van Rheenen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/870adc24b20d4709945c1f69dfd3f0c7
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spelling	oai:doaj.org-article:870adc24b20d4709945c1f69dfd3f0c72021-12-02T11:52:40ZPreventing inflammation inhibits biopsy-mediated changes in tumor cell behavior10.1038/s41598-017-07660-42045-2322https://doaj.org/article/870adc24b20d4709945c1f69dfd3f0c72017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07660-4https://doaj.org/toc/2045-2322Abstract Although biopsies and tumor resection are prognostically beneficial for glioblastomas (GBM), potential negative effects have also been suggested. Here, using retrospective study of patients and intravital imaging of mice, we identify some of these negative aspects, including stimulation of proliferation and migration of non-resected tumor cells, and provide a strategy to prevent these adverse effects. By repeated high-resolution intravital microscopy, we show that biopsy-like injury in GBM induces migration and proliferation of tumor cells through chemokine (C-C motif) ligand 2 (CCL-2)-dependent recruitment of macrophages. Blocking macrophage recruitment or administrating dexamethasone, a commonly used glucocorticoid to prevent brain edema in GBM patients, suppressed the observed inflammatory response and subsequent tumor growth upon biopsy both in mice and in multifocal GBM patients. Taken together, our study suggests that inhibiting CCL-2-dependent recruitment of macrophages may further increase the clinical benefits from surgical and biopsy procedures.Maria AlievaAndreia S. MargaridoTamara WielesErik R. AbelsBurcin ColakCarla BoquetaleHerke Jan NoordmansTom J. SnijdersMarike L. BroekmanJacco van RheenenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Alieva Andreia S. Margarido Tamara Wieles Erik R. Abels Burcin Colak Carla Boquetale Herke Jan Noordmans Tom J. Snijders Marike L. Broekman Jacco van Rheenen Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior
description	Abstract Although biopsies and tumor resection are prognostically beneficial for glioblastomas (GBM), potential negative effects have also been suggested. Here, using retrospective study of patients and intravital imaging of mice, we identify some of these negative aspects, including stimulation of proliferation and migration of non-resected tumor cells, and provide a strategy to prevent these adverse effects. By repeated high-resolution intravital microscopy, we show that biopsy-like injury in GBM induces migration and proliferation of tumor cells through chemokine (C-C motif) ligand 2 (CCL-2)-dependent recruitment of macrophages. Blocking macrophage recruitment or administrating dexamethasone, a commonly used glucocorticoid to prevent brain edema in GBM patients, suppressed the observed inflammatory response and subsequent tumor growth upon biopsy both in mice and in multifocal GBM patients. Taken together, our study suggests that inhibiting CCL-2-dependent recruitment of macrophages may further increase the clinical benefits from surgical and biopsy procedures.
format	article
author	Maria Alieva Andreia S. Margarido Tamara Wieles Erik R. Abels Burcin Colak Carla Boquetale Herke Jan Noordmans Tom J. Snijders Marike L. Broekman Jacco van Rheenen
author_facet	Maria Alieva Andreia S. Margarido Tamara Wieles Erik R. Abels Burcin Colak Carla Boquetale Herke Jan Noordmans Tom J. Snijders Marike L. Broekman Jacco van Rheenen
author_sort	Maria Alieva
title	Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior
title_short	Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior
title_full	Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior
title_fullStr	Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior
title_full_unstemmed	Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior
title_sort	preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/870adc24b20d4709945c1f69dfd3f0c7
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Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior

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