An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels

Intercellular signalling can be mediated by gap junction channels, and calcium blocks this signally during tissue injury. Here, the authors use X-ray crystallography and molecular dynamics to show that the calcium forms an electrostatic barrier to prevent transport of cations.

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Autores principales:	Brad C. Bennett, Michael D. Purdy, Kent A. Baker, Chayan Acharya, William E. McIntire, Raymond C. Stevens, Qinghai Zhang, Andrew L. Harris, Ruben Abagyan, Mark Yeager
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8711c8402a1e467da4c3721f1fe65a53
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spelling	oai:doaj.org-article:8711c8402a1e467da4c3721f1fe65a532021-12-02T14:38:57ZAn electrostatic mechanism for Ca2+-mediated regulation of gap junction channels10.1038/ncomms97702041-1723https://doaj.org/article/8711c8402a1e467da4c3721f1fe65a532016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms9770https://doaj.org/toc/2041-1723Intercellular signalling can be mediated by gap junction channels, and calcium blocks this signally during tissue injury. Here, the authors use X-ray crystallography and molecular dynamics to show that the calcium forms an electrostatic barrier to prevent transport of cations.Brad C. BennettMichael D. PurdyKent A. BakerChayan AcharyaWilliam E. McIntireRaymond C. StevensQinghai ZhangAndrew L. HarrisRuben AbagyanMark YeagerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brad C. Bennett Michael D. Purdy Kent A. Baker Chayan Acharya William E. McIntire Raymond C. Stevens Qinghai Zhang Andrew L. Harris Ruben Abagyan Mark Yeager An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels
description	Intercellular signalling can be mediated by gap junction channels, and calcium blocks this signally during tissue injury. Here, the authors use X-ray crystallography and molecular dynamics to show that the calcium forms an electrostatic barrier to prevent transport of cations.
format	article
author	Brad C. Bennett Michael D. Purdy Kent A. Baker Chayan Acharya William E. McIntire Raymond C. Stevens Qinghai Zhang Andrew L. Harris Ruben Abagyan Mark Yeager
author_facet	Brad C. Bennett Michael D. Purdy Kent A. Baker Chayan Acharya William E. McIntire Raymond C. Stevens Qinghai Zhang Andrew L. Harris Ruben Abagyan Mark Yeager
author_sort	Brad C. Bennett
title	An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels
title_short	An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels
title_full	An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels
title_fullStr	An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels
title_full_unstemmed	An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels
title_sort	electrostatic mechanism for ca2+-mediated regulation of gap junction channels
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/8711c8402a1e467da4c3721f1fe65a53
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An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels

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