Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis

Aberrant chromatin structure is often found in cancer. Here, the authors optimise super-resolution microscopy for pathological tissue and discovered a significant decompaction of chromatin folding in early carcinogenesis prior to tumour formation.

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Main Authors:	Jianquan Xu, Hongqiang Ma, Hongbin Ma, Wei Jiang, Christopher A. Mela, Meihan Duan, Shimei Zhao, Chenxi Gao, Eun-Ryeong Hahm, Santana M. Lardo, Kris Troy, Ming Sun, Reet Pai, Donna B. Stolz, Lin Zhang, Shivendra Singh, Randall E. Brand, Douglas J. Hartman, Jing Hu, Sarah J. Hainer, Yang Liu
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/8713c6ce28ab4d18b94e1dfd7c1d1570
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spelling	oai:doaj.org-article:8713c6ce28ab4d18b94e1dfd7c1d15702021-12-02T14:40:42ZSuper-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis10.1038/s41467-020-15718-72041-1723https://doaj.org/article/8713c6ce28ab4d18b94e1dfd7c1d15702020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15718-7https://doaj.org/toc/2041-1723Aberrant chromatin structure is often found in cancer. Here, the authors optimise super-resolution microscopy for pathological tissue and discovered a significant decompaction of chromatin folding in early carcinogenesis prior to tumour formation.Jianquan XuHongqiang MaHongbin MaWei JiangChristopher A. MelaMeihan DuanShimei ZhaoChenxi GaoEun-Ryeong HahmSantana M. LardoKris TroyMing SunReet PaiDonna B. StolzLin ZhangShivendra SinghRandall E. BrandDouglas J. HartmanJing HuSarah J. HainerYang LiuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jianquan Xu Hongqiang Ma Hongbin Ma Wei Jiang Christopher A. Mela Meihan Duan Shimei Zhao Chenxi Gao Eun-Ryeong Hahm Santana M. Lardo Kris Troy Ming Sun Reet Pai Donna B. Stolz Lin Zhang Shivendra Singh Randall E. Brand Douglas J. Hartman Jing Hu Sarah J. Hainer Yang Liu Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis
description	Aberrant chromatin structure is often found in cancer. Here, the authors optimise super-resolution microscopy for pathological tissue and discovered a significant decompaction of chromatin folding in early carcinogenesis prior to tumour formation.
format	article
author	Jianquan Xu Hongqiang Ma Hongbin Ma Wei Jiang Christopher A. Mela Meihan Duan Shimei Zhao Chenxi Gao Eun-Ryeong Hahm Santana M. Lardo Kris Troy Ming Sun Reet Pai Donna B. Stolz Lin Zhang Shivendra Singh Randall E. Brand Douglas J. Hartman Jing Hu Sarah J. Hainer Yang Liu
author_facet	Jianquan Xu Hongqiang Ma Hongbin Ma Wei Jiang Christopher A. Mela Meihan Duan Shimei Zhao Chenxi Gao Eun-Ryeong Hahm Santana M. Lardo Kris Troy Ming Sun Reet Pai Donna B. Stolz Lin Zhang Shivendra Singh Randall E. Brand Douglas J. Hartman Jing Hu Sarah J. Hainer Yang Liu
author_sort	Jianquan Xu
title	Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis
title_short	Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis
title_full	Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis
title_fullStr	Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis
title_full_unstemmed	Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis
title_sort	super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8713c6ce28ab4d18b94e1dfd7c1d1570
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Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis

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