CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2

Tissue-resident memory T cells are needed for optimal antiviral immunity at mucosal surfaces. Here the authors provide a mechanism for this protection, showing that vaginal CD301b+ DC-dependent IFN-γ production by CD8+ tissue-resident memory T cells, not circulating T cells, is central to HSV-2 resi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Haina Shin, Yosuke Kumamoto, Smita Gopinath, Akiko Iwasaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/87140be6976e47719aa4d031e25a7757
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:87140be6976e47719aa4d031e25a7757
record_format	dspace
spelling	oai:doaj.org-article:87140be6976e47719aa4d031e25a77572021-12-02T14:39:52ZCD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-210.1038/ncomms133462041-1723https://doaj.org/article/87140be6976e47719aa4d031e25a77572016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13346https://doaj.org/toc/2041-1723Tissue-resident memory T cells are needed for optimal antiviral immunity at mucosal surfaces. Here the authors provide a mechanism for this protection, showing that vaginal CD301b+ DC-dependent IFN-γ production by CD8+ tissue-resident memory T cells, not circulating T cells, is central to HSV-2 resistance.Haina ShinYosuke KumamotoSmita GopinathAkiko IwasakiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haina Shin Yosuke Kumamoto Smita Gopinath Akiko Iwasaki CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2
description	Tissue-resident memory T cells are needed for optimal antiviral immunity at mucosal surfaces. Here the authors provide a mechanism for this protection, showing that vaginal CD301b+ DC-dependent IFN-γ production by CD8+ tissue-resident memory T cells, not circulating T cells, is central to HSV-2 resistance.
format	article
author	Haina Shin Yosuke Kumamoto Smita Gopinath Akiko Iwasaki
author_facet	Haina Shin Yosuke Kumamoto Smita Gopinath Akiko Iwasaki
author_sort	Haina Shin
title	CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2
title_short	CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2
title_full	CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2
title_fullStr	CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2
title_full_unstemmed	CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2
title_sort	cd301b+ dendritic cells stimulate tissue-resident memory cd8+ t cells to protect against genital hsv-2
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/87140be6976e47719aa4d031e25a7757
work_keys_str_mv	AT hainashin cd301bdendriticcellsstimulatetissueresidentmemorycd8tcellstoprotectagainstgenitalhsv2 AT yosukekumamoto cd301bdendriticcellsstimulatetissueresidentmemorycd8tcellstoprotectagainstgenitalhsv2 AT smitagopinath cd301bdendriticcellsstimulatetissueresidentmemorycd8tcellstoprotectagainstgenitalhsv2 AT akikoiwasaki cd301bdendriticcellsstimulatetissueresidentmemorycd8tcellstoprotectagainstgenitalhsv2
_version_	1718390484190101504

CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2

Ejemplares similares