Non-invasive characterization of human bone marrow stimulation and reconstitution by cell-free messenger RNA sequencing

Non-invasive characterization of human bone marrow stimulation and reconstitution by cell-free messenger RNA sequencing

Circulating cell-free mRNA holds great promise as a non-invasive diagnostic biomarker. Here the authors show that cell-free mRNA captures transcripts from the bone marrow and can be used to non-invasively monitor dynamic changes in bone marrow physiology.

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Detalles Bibliográficos
Autores principales: Arkaitz Ibarra, Jiali Zhuang, Yue Zhao, Neeraj S. Salathia, Vera Huang, Alexander D. Acosta, Jonathan Aballi, Shusuke Toden, Amy P. Karns, Intan Purnajo, Julianna R. Parks, Lucy Guo, James Mason, Darren Sigal, Tina S. Nova, Stephen R. Quake, Michael Nerenberg
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/87196fe47ad34f7e87daf12fccf54685
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Descripción
Sumario:Circulating cell-free mRNA holds great promise as a non-invasive diagnostic biomarker. Here the authors show that cell-free mRNA captures transcripts from the bone marrow and can be used to non-invasively monitor dynamic changes in bone marrow physiology.

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