Non-invasive characterization of human bone marrow stimulation and reconstitution by cell-free messenger RNA sequencing

Circulating cell-free mRNA holds great promise as a non-invasive diagnostic biomarker. Here the authors show that cell-free mRNA captures transcripts from the bone marrow and can be used to non-invasively monitor dynamic changes in bone marrow physiology.

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Bibliographic Details
Main Authors:	Arkaitz Ibarra, Jiali Zhuang, Yue Zhao, Neeraj S. Salathia, Vera Huang, Alexander D. Acosta, Jonathan Aballi, Shusuke Toden, Amy P. Karns, Intan Purnajo, Julianna R. Parks, Lucy Guo, James Mason, Darren Sigal, Tina S. Nova, Stephen R. Quake, Michael Nerenberg
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/87196fe47ad34f7e87daf12fccf54685
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spelling	oai:doaj.org-article:87196fe47ad34f7e87daf12fccf546852021-12-02T15:33:50ZNon-invasive characterization of human bone marrow stimulation and reconstitution by cell-free messenger RNA sequencing10.1038/s41467-019-14253-42041-1723https://doaj.org/article/87196fe47ad34f7e87daf12fccf546852020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14253-4https://doaj.org/toc/2041-1723Circulating cell-free mRNA holds great promise as a non-invasive diagnostic biomarker. Here the authors show that cell-free mRNA captures transcripts from the bone marrow and can be used to non-invasively monitor dynamic changes in bone marrow physiology.Arkaitz IbarraJiali ZhuangYue ZhaoNeeraj S. SalathiaVera HuangAlexander D. AcostaJonathan AballiShusuke TodenAmy P. KarnsIntan PurnajoJulianna R. ParksLucy GuoJames MasonDarren SigalTina S. NovaStephen R. QuakeMichael NerenbergNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arkaitz Ibarra Jiali Zhuang Yue Zhao Neeraj S. Salathia Vera Huang Alexander D. Acosta Jonathan Aballi Shusuke Toden Amy P. Karns Intan Purnajo Julianna R. Parks Lucy Guo James Mason Darren Sigal Tina S. Nova Stephen R. Quake Michael Nerenberg Non-invasive characterization of human bone marrow stimulation and reconstitution by cell-free messenger RNA sequencing
description	Circulating cell-free mRNA holds great promise as a non-invasive diagnostic biomarker. Here the authors show that cell-free mRNA captures transcripts from the bone marrow and can be used to non-invasively monitor dynamic changes in bone marrow physiology.
format	article
author	Arkaitz Ibarra Jiali Zhuang Yue Zhao Neeraj S. Salathia Vera Huang Alexander D. Acosta Jonathan Aballi Shusuke Toden Amy P. Karns Intan Purnajo Julianna R. Parks Lucy Guo James Mason Darren Sigal Tina S. Nova Stephen R. Quake Michael Nerenberg
author_facet	Arkaitz Ibarra Jiali Zhuang Yue Zhao Neeraj S. Salathia Vera Huang Alexander D. Acosta Jonathan Aballi Shusuke Toden Amy P. Karns Intan Purnajo Julianna R. Parks Lucy Guo James Mason Darren Sigal Tina S. Nova Stephen R. Quake Michael Nerenberg
author_sort	Arkaitz Ibarra
title	Non-invasive characterization of human bone marrow stimulation and reconstitution by cell-free messenger RNA sequencing
title_short	Non-invasive characterization of human bone marrow stimulation and reconstitution by cell-free messenger RNA sequencing
title_full	Non-invasive characterization of human bone marrow stimulation and reconstitution by cell-free messenger RNA sequencing
title_fullStr	Non-invasive characterization of human bone marrow stimulation and reconstitution by cell-free messenger RNA sequencing
title_full_unstemmed	Non-invasive characterization of human bone marrow stimulation and reconstitution by cell-free messenger RNA sequencing
title_sort	non-invasive characterization of human bone marrow stimulation and reconstitution by cell-free messenger rna sequencing
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/87196fe47ad34f7e87daf12fccf54685
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Non-invasive characterization of human bone marrow stimulation and reconstitution by cell-free messenger RNA sequencing

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