Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo.

<h4>Background</h4>Ebola virus (EBOV) is a zoonotic filovirus spread through exposure to infected bodily fluids of a human or animal. Though EBOV is capable of causing severe disease, referred to as Ebola Virus Disease (EVD), individuals who have never been diagnosed with confirmed, prob...

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Autores principales:	Anna Bratcher, Nicole A Hoff, Reena H Doshi, Adva Gadoth, Megan Halbrook, Patrick Mukadi, Kamy Musene, Benoit Ilunga-Kebela, D'Andre Spencer, Matthew S Bramble, David McIlwan, J Daniel Kelly, Daniel Mukadi, Placide Mbala Kingebeni, Steve Ahuka, Emile Okitolonda-Wemakoy, Jean-Jacques Muyembe-Tamfum, Anne W Rimoin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/871d5746511a4940b0221940a83b5424
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spelling	oai:doaj.org-article:871d5746511a4940b0221940a83b54242021-12-02T20:23:40ZZoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo.1935-27271935-273510.1371/journal.pntd.0009566https://doaj.org/article/871d5746511a4940b0221940a83b54242021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009566https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Ebola virus (EBOV) is a zoonotic filovirus spread through exposure to infected bodily fluids of a human or animal. Though EBOV is capable of causing severe disease, referred to as Ebola Virus Disease (EVD), individuals who have never been diagnosed with confirmed, probable or suspected EVD can have detectable EBOV antigen-specific antibodies in their blood. This study aims to identify risk factors associated with detectable antibody levels in the absence of an EVD diagnosis.<h4>Methodology</h4>Data was collected from September 2015 to August 2017 from 1,366 consenting individuals across four study sites in the DRC (Boende, Kabondo-Dianda, Kikwit, and Yambuku). Seroreactivity was determined to EBOV GP IgG using Zaire Ebola Virus Glycoprotein (EBOV GP antigen) ELISA kits (Alpha Diagnostic International, Inc.) in Kinshasa, DRC; any result above 4.7 units/mL was considered seroreactive. Among the respondents, 113 (8.3%) were considered seroreactive. Several zoonotic exposures were associated with EBOV seroreactivity after controlling for age, sex, healthcare worker status, location, and history of contact with an EVD case, namely: ever having contact with bats, ever having contact with rodents, and ever eating non-human primate meat. Contact with monkeys or non-human primates was not associated with seroreactivity.<h4>Conclusions</h4>This analysis suggests that some zoonotic exposures that have been linked to EVD outbreaks can also be associated with EBOV GP seroreactivity in the absence of diagnosed EVD. Future investigations should seek to clarify the relationships between zoonotic exposures, seroreactivity, asymptomatic infection, and EVD.Anna BratcherNicole A HoffReena H DoshiAdva GadothMegan HalbrookPatrick MukadiKamy MuseneBenoit Ilunga-KebelaD'Andre SpencerMatthew S BrambleDavid McIlwanJ Daniel KellyDaniel MukadiPlacide Mbala KingebeniSteve AhukaEmile Okitolonda-WemakoyJean-Jacques Muyembe-TamfumAnne W RimoinPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009566 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Anna Bratcher Nicole A Hoff Reena H Doshi Adva Gadoth Megan Halbrook Patrick Mukadi Kamy Musene Benoit Ilunga-Kebela D'Andre Spencer Matthew S Bramble David McIlwan J Daniel Kelly Daniel Mukadi Placide Mbala Kingebeni Steve Ahuka Emile Okitolonda-Wemakoy Jean-Jacques Muyembe-Tamfum Anne W Rimoin Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo.
description	<h4>Background</h4>Ebola virus (EBOV) is a zoonotic filovirus spread through exposure to infected bodily fluids of a human or animal. Though EBOV is capable of causing severe disease, referred to as Ebola Virus Disease (EVD), individuals who have never been diagnosed with confirmed, probable or suspected EVD can have detectable EBOV antigen-specific antibodies in their blood. This study aims to identify risk factors associated with detectable antibody levels in the absence of an EVD diagnosis.<h4>Methodology</h4>Data was collected from September 2015 to August 2017 from 1,366 consenting individuals across four study sites in the DRC (Boende, Kabondo-Dianda, Kikwit, and Yambuku). Seroreactivity was determined to EBOV GP IgG using Zaire Ebola Virus Glycoprotein (EBOV GP antigen) ELISA kits (Alpha Diagnostic International, Inc.) in Kinshasa, DRC; any result above 4.7 units/mL was considered seroreactive. Among the respondents, 113 (8.3%) were considered seroreactive. Several zoonotic exposures were associated with EBOV seroreactivity after controlling for age, sex, healthcare worker status, location, and history of contact with an EVD case, namely: ever having contact with bats, ever having contact with rodents, and ever eating non-human primate meat. Contact with monkeys or non-human primates was not associated with seroreactivity.<h4>Conclusions</h4>This analysis suggests that some zoonotic exposures that have been linked to EVD outbreaks can also be associated with EBOV GP seroreactivity in the absence of diagnosed EVD. Future investigations should seek to clarify the relationships between zoonotic exposures, seroreactivity, asymptomatic infection, and EVD.
format	article
author	Anna Bratcher Nicole A Hoff Reena H Doshi Adva Gadoth Megan Halbrook Patrick Mukadi Kamy Musene Benoit Ilunga-Kebela D'Andre Spencer Matthew S Bramble David McIlwan J Daniel Kelly Daniel Mukadi Placide Mbala Kingebeni Steve Ahuka Emile Okitolonda-Wemakoy Jean-Jacques Muyembe-Tamfum Anne W Rimoin
author_facet	Anna Bratcher Nicole A Hoff Reena H Doshi Adva Gadoth Megan Halbrook Patrick Mukadi Kamy Musene Benoit Ilunga-Kebela D'Andre Spencer Matthew S Bramble David McIlwan J Daniel Kelly Daniel Mukadi Placide Mbala Kingebeni Steve Ahuka Emile Okitolonda-Wemakoy Jean-Jacques Muyembe-Tamfum Anne W Rimoin
author_sort	Anna Bratcher
title	Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo.
title_short	Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo.
title_full	Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo.
title_fullStr	Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo.
title_full_unstemmed	Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo.
title_sort	zoonotic risk factors associated with seroprevalence of ebola virus gp antibodies in the absence of diagnosed ebola virus disease in the democratic republic of congo.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/871d5746511a4940b0221940a83b5424
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Zoonotic risk factors associated with seroprevalence of Ebola virus GP antibodies in the absence of diagnosed Ebola virus disease in the Democratic Republic of Congo.

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