Glucagon and alpha-cells as a novel therapeutic target in the management of diabetes mellitus

For the past several years, a number of studies addressed glucagon and its role in glycemic homeostasis and the development of diabetes mellitus. Current review discusses basic developmental stages of pancreatic islets with special regard for the role of beta-cells and basic mechanisms of g...

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Autores principales:	Nina Alexandrovna Petunina, Lyubov' Valentinovna Trukhina, Elena Igorevna Sinicyna, Marina Vladimirovna Shestakova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2013
Materias:	diabetes mellitus glucagon alpha-cells expression regulation functioning beta-cells incretins bioactive gastrointestinal hormones Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/871f530f1ce744a2a36ad38f5572a3b3
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id	oai:doaj.org-article:871f530f1ce744a2a36ad38f5572a3b3
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spelling	oai:doaj.org-article:871f530f1ce744a2a36ad38f5572a3b32021-11-14T09:00:18ZGlucagon and alpha-cells as a novel therapeutic target in the management of diabetes mellitus2072-03512072-037810.14341/2072-0351-815https://doaj.org/article/871f530f1ce744a2a36ad38f5572a3b32013-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/815https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378For the past several years, a number of studies addressed glucagon and its role in glycemic homeostasis and the development of diabetes mellitus. Current review discusses basic developmental stages of pancreatic islets with special regard for the role of beta-cells and basic mechanisms of glucagon function. We also highlight promising approaches to diabetes compensation based on adjustment of glucagon secretion.Nina Alexandrovna PetuninaLyubov' Valentinovna TrukhinaElena Igorevna SinicynaMarina Vladimirovna ShestakovaEndocrinology Research Centrearticlediabetes mellitusglucagonalpha-cellsexpression regulationfunctioning beta-cellsincretinsbioactive gastrointestinal hormonesNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 16, Iss 3, Pp 35-40 (2013)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus glucagon alpha-cells expression regulation functioning beta-cells incretins bioactive gastrointestinal hormones Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus glucagon alpha-cells expression regulation functioning beta-cells incretins bioactive gastrointestinal hormones Nutritional diseases. Deficiency diseases RC620-627 Nina Alexandrovna Petunina Lyubov' Valentinovna Trukhina Elena Igorevna Sinicyna Marina Vladimirovna Shestakova Glucagon and alpha-cells as a novel therapeutic target in the management of diabetes mellitus
description	For the past several years, a number of studies addressed glucagon and its role in glycemic homeostasis and the development of diabetes mellitus. Current review discusses basic developmental stages of pancreatic islets with special regard for the role of beta-cells and basic mechanisms of glucagon function. We also highlight promising approaches to diabetes compensation based on adjustment of glucagon secretion.
format	article
author	Nina Alexandrovna Petunina Lyubov' Valentinovna Trukhina Elena Igorevna Sinicyna Marina Vladimirovna Shestakova
author_facet	Nina Alexandrovna Petunina Lyubov' Valentinovna Trukhina Elena Igorevna Sinicyna Marina Vladimirovna Shestakova
author_sort	Nina Alexandrovna Petunina
title	Glucagon and alpha-cells as a novel therapeutic target in the management of diabetes mellitus
title_short	Glucagon and alpha-cells as a novel therapeutic target in the management of diabetes mellitus
title_full	Glucagon and alpha-cells as a novel therapeutic target in the management of diabetes mellitus
title_fullStr	Glucagon and alpha-cells as a novel therapeutic target in the management of diabetes mellitus
title_full_unstemmed	Glucagon and alpha-cells as a novel therapeutic target in the management of diabetes mellitus
title_sort	glucagon and alpha-cells as a novel therapeutic target in the management of diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2013
url	https://doaj.org/article/871f530f1ce744a2a36ad38f5572a3b3
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Glucagon and alpha-cells as a novel therapeutic target in the management of diabetes mellitus

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