Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model

Combining different types of immune therapies might benefit certain patients. Here, the authors develop an autologous immune-humanized melanoma mouse model that allows the preclinical assessment of cancer cell–T cell interactions from each individual patient and the benefits of immunotherapies combi...

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Autores principales: Henrik Jespersen, Mattias F. Lindberg, Marco Donia, Elin M. V. Söderberg, Rikke Andersen, Ulrich Keller, Lars Ny, Inge Marie Svane, Lisa M. Nilsson, Jonas A. Nilsson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/872053043156473e8e20cc09cdc48cb0
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Sumario:Combining different types of immune therapies might benefit certain patients. Here, the authors develop an autologous immune-humanized melanoma mouse model that allows the preclinical assessment of cancer cell–T cell interactions from each individual patient and the benefits of immunotherapies combinations.