Iliski, a software for robust calculation of transfer functions.

Understanding the relationships between biological processes is paramount to unravel pathophysiological mechanisms. These relationships can be modeled with Transfer Functions (TFs), with no need of a priori hypotheses as to the shape of the transfer function. Here we present Iliski, a software dedic...

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Autores principales:	Ali-Kemal Aydin, William D Haselden, Julie Dang, Patrick J Drew, Serge Charpak, Davide Boido
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8720c67540d14f74a4028b13733b46a3
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spelling	oai:doaj.org-article:8720c67540d14f74a4028b13733b46a32021-12-02T19:58:09ZIliski, a software for robust calculation of transfer functions.1553-734X1553-735810.1371/journal.pcbi.1008614https://doaj.org/article/8720c67540d14f74a4028b13733b46a32021-06-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1008614https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Understanding the relationships between biological processes is paramount to unravel pathophysiological mechanisms. These relationships can be modeled with Transfer Functions (TFs), with no need of a priori hypotheses as to the shape of the transfer function. Here we present Iliski, a software dedicated to TFs computation between two signals. It includes different pre-treatment routines and TF computation processes: deconvolution, deterministic and non-deterministic optimization algorithms that are adapted to disparate datasets. We apply Iliski to data on neurovascular coupling, an ensemble of cellular mechanisms that link neuronal activity to local changes of blood flow, highlighting the software benefits and caveats in the computation and evaluation of TFs. We also propose a workflow that will help users to choose the best computation according to the dataset. Iliski is available under the open-source license CC BY 4.0 on GitHub (https://github.com/alike-aydin/Iliski) and can be used on the most common operating systems, either within the MATLAB environment, or as a standalone application.Ali-Kemal AydinWilliam D HaseldenJulie DangPatrick J DrewSerge CharpakDavide BoidoPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 6, p e1008614 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ali-Kemal Aydin William D Haselden Julie Dang Patrick J Drew Serge Charpak Davide Boido Iliski, a software for robust calculation of transfer functions.
description	Understanding the relationships between biological processes is paramount to unravel pathophysiological mechanisms. These relationships can be modeled with Transfer Functions (TFs), with no need of a priori hypotheses as to the shape of the transfer function. Here we present Iliski, a software dedicated to TFs computation between two signals. It includes different pre-treatment routines and TF computation processes: deconvolution, deterministic and non-deterministic optimization algorithms that are adapted to disparate datasets. We apply Iliski to data on neurovascular coupling, an ensemble of cellular mechanisms that link neuronal activity to local changes of blood flow, highlighting the software benefits and caveats in the computation and evaluation of TFs. We also propose a workflow that will help users to choose the best computation according to the dataset. Iliski is available under the open-source license CC BY 4.0 on GitHub (https://github.com/alike-aydin/Iliski) and can be used on the most common operating systems, either within the MATLAB environment, or as a standalone application.
format	article
author	Ali-Kemal Aydin William D Haselden Julie Dang Patrick J Drew Serge Charpak Davide Boido
author_facet	Ali-Kemal Aydin William D Haselden Julie Dang Patrick J Drew Serge Charpak Davide Boido
author_sort	Ali-Kemal Aydin
title	Iliski, a software for robust calculation of transfer functions.
title_short	Iliski, a software for robust calculation of transfer functions.
title_full	Iliski, a software for robust calculation of transfer functions.
title_fullStr	Iliski, a software for robust calculation of transfer functions.
title_full_unstemmed	Iliski, a software for robust calculation of transfer functions.
title_sort	iliski, a software for robust calculation of transfer functions.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8720c67540d14f74a4028b13733b46a3
work_keys_str_mv	AT alikemalaydin iliskiasoftwareforrobustcalculationoftransferfunctions AT williamdhaselden iliskiasoftwareforrobustcalculationoftransferfunctions AT juliedang iliskiasoftwareforrobustcalculationoftransferfunctions AT patrickjdrew iliskiasoftwareforrobustcalculationoftransferfunctions AT sergecharpak iliskiasoftwareforrobustcalculationoftransferfunctions AT davideboido iliskiasoftwareforrobustcalculationoftransferfunctions
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Iliski, a software for robust calculation of transfer functions.

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