Immunological tolerance to muscle autoantigens involves peripheral deletion of autoreactive CD8+ T cells.

Muscle potentially represents the most abundant source of autoantigens of the body and can be targeted by a variety of severe autoimmune diseases. Yet, the mechanisms of immunological tolerance toward muscle autoantigens remain mostly unknown. We investigated this issue in transgenic SM-Ova mice tha...

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Autores principales: Emilie Franck, Carole Bonneau, Laetitia Jean, Jean-Paul Henry, Yann Lacoume, Anna Salvetti, Olivier Boyer, Sahil Adriouch
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/8724d9f9a2154f7da79f0107e5c6497b
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