Alterations of cerebral perfusion in asymptomatic internal carotid artery steno-occlusive disease

Abstract Patients with asymptomatic occlusion in the internal carotid arteries (ICA) have been shown to have a better preserved hemodynamic status of the brain as compared to patients with symptoms. This study was aimed to explore the cerebral perfusion alterations in asymptomatic patients using mul...

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Autores principales:	Ya-Fang Chen, Sung-Chun Tang, Wen-Chau Wu, Hsien-Li Kao, Yen-Shu Kuo, Shun-Chung Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/87289e7cff254f6ab39a095ef4bbd106
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spelling	oai:doaj.org-article:87289e7cff254f6ab39a095ef4bbd1062021-12-02T12:30:12ZAlterations of cerebral perfusion in asymptomatic internal carotid artery steno-occlusive disease10.1038/s41598-017-02094-42045-2322https://doaj.org/article/87289e7cff254f6ab39a095ef4bbd1062017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02094-4https://doaj.org/toc/2045-2322Abstract Patients with asymptomatic occlusion in the internal carotid arteries (ICA) have been shown to have a better preserved hemodynamic status of the brain as compared to patients with symptoms. This study was aimed to explore the cerebral perfusion alterations in asymptomatic patients using multi-parametric arterial spin-labeling (ASL) magnetic resonance (MR) imaging. Forty-two patients diagnosed with asymptomatic ICA stenosis/occlusion were prospectively included and divided into high-grade (ultrasonographic stenosis ≥70%, N = 20) and low-grade groups (N = 22). On a 3-Tesla clinical MR scanner, pseudo-continuous ASL was performed to measure cerebral blood flow CBF, arterial transit time ATT, and flow territory. Fisher’s exact test indicates that the high-grade group has higher frequency in asymmetric ATT (p < 10−3) and asymmetric flow territory (p < 10−3) as compared to the low-grade group. The between-group difference in CBF asymmetry is marginal (p = 0.062). Logistic regression further reveals that hemispherical asymmetry in ATT and flow territory is associated with the existence of high-grade ICA stenosis (odds ratio = 12 and 21, respectively), whereas hemispherical asymmetry in CBF is not. Our data suggest that ATT and flow territory may be better predictors of asymptomatic high-grade ICA stenosis diagnosed by carotid ultrasonography than CBF.Ya-Fang ChenSung-Chun TangWen-Chau WuHsien-Li KaoYen-Shu KuoShun-Chung YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ya-Fang Chen Sung-Chun Tang Wen-Chau Wu Hsien-Li Kao Yen-Shu Kuo Shun-Chung Yang Alterations of cerebral perfusion in asymptomatic internal carotid artery steno-occlusive disease
description	Abstract Patients with asymptomatic occlusion in the internal carotid arteries (ICA) have been shown to have a better preserved hemodynamic status of the brain as compared to patients with symptoms. This study was aimed to explore the cerebral perfusion alterations in asymptomatic patients using multi-parametric arterial spin-labeling (ASL) magnetic resonance (MR) imaging. Forty-two patients diagnosed with asymptomatic ICA stenosis/occlusion were prospectively included and divided into high-grade (ultrasonographic stenosis ≥70%, N = 20) and low-grade groups (N = 22). On a 3-Tesla clinical MR scanner, pseudo-continuous ASL was performed to measure cerebral blood flow CBF, arterial transit time ATT, and flow territory. Fisher’s exact test indicates that the high-grade group has higher frequency in asymmetric ATT (p < 10−3) and asymmetric flow territory (p < 10−3) as compared to the low-grade group. The between-group difference in CBF asymmetry is marginal (p = 0.062). Logistic regression further reveals that hemispherical asymmetry in ATT and flow territory is associated with the existence of high-grade ICA stenosis (odds ratio = 12 and 21, respectively), whereas hemispherical asymmetry in CBF is not. Our data suggest that ATT and flow territory may be better predictors of asymptomatic high-grade ICA stenosis diagnosed by carotid ultrasonography than CBF.
format	article
author	Ya-Fang Chen Sung-Chun Tang Wen-Chau Wu Hsien-Li Kao Yen-Shu Kuo Shun-Chung Yang
author_facet	Ya-Fang Chen Sung-Chun Tang Wen-Chau Wu Hsien-Li Kao Yen-Shu Kuo Shun-Chung Yang
author_sort	Ya-Fang Chen
title	Alterations of cerebral perfusion in asymptomatic internal carotid artery steno-occlusive disease
title_short	Alterations of cerebral perfusion in asymptomatic internal carotid artery steno-occlusive disease
title_full	Alterations of cerebral perfusion in asymptomatic internal carotid artery steno-occlusive disease
title_fullStr	Alterations of cerebral perfusion in asymptomatic internal carotid artery steno-occlusive disease
title_full_unstemmed	Alterations of cerebral perfusion in asymptomatic internal carotid artery steno-occlusive disease
title_sort	alterations of cerebral perfusion in asymptomatic internal carotid artery steno-occlusive disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/87289e7cff254f6ab39a095ef4bbd106
work_keys_str_mv	AT yafangchen alterationsofcerebralperfusioninasymptomaticinternalcarotidarterystenoocclusivedisease AT sungchuntang alterationsofcerebralperfusioninasymptomaticinternalcarotidarterystenoocclusivedisease AT wenchauwu alterationsofcerebralperfusioninasymptomaticinternalcarotidarterystenoocclusivedisease AT hsienlikao alterationsofcerebralperfusioninasymptomaticinternalcarotidarterystenoocclusivedisease AT yenshukuo alterationsofcerebralperfusioninasymptomaticinternalcarotidarterystenoocclusivedisease AT shunchungyang alterationsofcerebralperfusioninasymptomaticinternalcarotidarterystenoocclusivedisease
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Alterations of cerebral perfusion in asymptomatic internal carotid artery steno-occlusive disease

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