Influenza vaccine effectiveness against hospitalisation with confirmed influenza in the 2010-11 seasons: a test-negative observational study.
Immunisation programs are designed to reduce serious morbidity and mortality from influenza, but most evidence supporting the effectiveness of this intervention has focused on disease in the community or in primary care settings. We aimed to examine the effectiveness of influenza vaccination against...
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2013
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oai:doaj.org-article:872927360ddc46dd95a5adf60de2828c2021-11-18T07:37:31ZInfluenza vaccine effectiveness against hospitalisation with confirmed influenza in the 2010-11 seasons: a test-negative observational study.1932-620310.1371/journal.pone.0068760https://doaj.org/article/872927360ddc46dd95a5adf60de2828c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23874754/?tool=EBIhttps://doaj.org/toc/1932-6203Immunisation programs are designed to reduce serious morbidity and mortality from influenza, but most evidence supporting the effectiveness of this intervention has focused on disease in the community or in primary care settings. We aimed to examine the effectiveness of influenza vaccination against hospitalisation with confirmed influenza. We compared influenza vaccination status in patients hospitalised with PCR-confirmed influenza with patients hospitalised with influenza-negative respiratory infections in an Australian sentinel surveillance system. Vaccine effectiveness was estimated from the odds ratio of vaccination in cases and controls. We performed both simple multivariate regression and a stratified analysis based on propensity score of vaccination. Vaccination status was ascertained in 333 of 598 patients with confirmed influenza and 785 of 1384 test-negative patients. Overall estimated crude vaccine effectiveness was 57% (41%, 68%). After adjusting for age, chronic comorbidities and pregnancy status, the estimated vaccine effectiveness was 37% (95% CI: 12%, 55%). In an analysis accounting for a propensity score for vaccination, the estimated vaccine effectiveness was 48.3% (95% CI: 30.0, 61.8%). Influenza vaccination was moderately protective against hospitalisation with influenza in the 2010 and 2011 seasons.Allen C ChengMark HolmesLouis B IrvingSimon G A BrownGrant W WatererTony M KormanN Deborah FriedmanSanjaya SenanayakeDominic E DwyerStephen BradyGrahame SimpsonRichard Wood-BakerJohn UphamDavid PatersonChristine JenkinsPeter WarkPaul M KellyTom KotsimbosPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e68760 (2013) |
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DOAJ |
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Medicine R Science Q |
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Medicine R Science Q Allen C Cheng Mark Holmes Louis B Irving Simon G A Brown Grant W Waterer Tony M Korman N Deborah Friedman Sanjaya Senanayake Dominic E Dwyer Stephen Brady Grahame Simpson Richard Wood-Baker John Upham David Paterson Christine Jenkins Peter Wark Paul M Kelly Tom Kotsimbos Influenza vaccine effectiveness against hospitalisation with confirmed influenza in the 2010-11 seasons: a test-negative observational study. |
| description |
Immunisation programs are designed to reduce serious morbidity and mortality from influenza, but most evidence supporting the effectiveness of this intervention has focused on disease in the community or in primary care settings. We aimed to examine the effectiveness of influenza vaccination against hospitalisation with confirmed influenza. We compared influenza vaccination status in patients hospitalised with PCR-confirmed influenza with patients hospitalised with influenza-negative respiratory infections in an Australian sentinel surveillance system. Vaccine effectiveness was estimated from the odds ratio of vaccination in cases and controls. We performed both simple multivariate regression and a stratified analysis based on propensity score of vaccination. Vaccination status was ascertained in 333 of 598 patients with confirmed influenza and 785 of 1384 test-negative patients. Overall estimated crude vaccine effectiveness was 57% (41%, 68%). After adjusting for age, chronic comorbidities and pregnancy status, the estimated vaccine effectiveness was 37% (95% CI: 12%, 55%). In an analysis accounting for a propensity score for vaccination, the estimated vaccine effectiveness was 48.3% (95% CI: 30.0, 61.8%). Influenza vaccination was moderately protective against hospitalisation with influenza in the 2010 and 2011 seasons. |
| format |
article |
| author |
Allen C Cheng Mark Holmes Louis B Irving Simon G A Brown Grant W Waterer Tony M Korman N Deborah Friedman Sanjaya Senanayake Dominic E Dwyer Stephen Brady Grahame Simpson Richard Wood-Baker John Upham David Paterson Christine Jenkins Peter Wark Paul M Kelly Tom Kotsimbos |
| author_facet |
Allen C Cheng Mark Holmes Louis B Irving Simon G A Brown Grant W Waterer Tony M Korman N Deborah Friedman Sanjaya Senanayake Dominic E Dwyer Stephen Brady Grahame Simpson Richard Wood-Baker John Upham David Paterson Christine Jenkins Peter Wark Paul M Kelly Tom Kotsimbos |
| author_sort |
Allen C Cheng |
| title |
Influenza vaccine effectiveness against hospitalisation with confirmed influenza in the 2010-11 seasons: a test-negative observational study. |
| title_short |
Influenza vaccine effectiveness against hospitalisation with confirmed influenza in the 2010-11 seasons: a test-negative observational study. |
| title_full |
Influenza vaccine effectiveness against hospitalisation with confirmed influenza in the 2010-11 seasons: a test-negative observational study. |
| title_fullStr |
Influenza vaccine effectiveness against hospitalisation with confirmed influenza in the 2010-11 seasons: a test-negative observational study. |
| title_full_unstemmed |
Influenza vaccine effectiveness against hospitalisation with confirmed influenza in the 2010-11 seasons: a test-negative observational study. |
| title_sort |
influenza vaccine effectiveness against hospitalisation with confirmed influenza in the 2010-11 seasons: a test-negative observational study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/872927360ddc46dd95a5adf60de2828c |
| work_keys_str_mv |
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| _version_ |
1718423173162074112 |