Application of High-Z Gold Nanoparticles in Targeted Cancer Radiotherapy—Pharmacokinetic Modeling, Monte Carlo Simulation and Radiobiological Effect Modeling

High-Z gold nanoparticles (AuNPs) conjugated to a targeting antibody can help to improve tumor control in radiotherapy while simultaneously minimizing radiotoxicity to adjacent healthy tissue. This paper summarizes the main findings of a joint research program which applied AuNP-conjugates in precli...

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Auteurs principaux: Wei Bo Li, Stefan Stangl, Alexander Klapproth, Maxim Shevtsov, Alicia Hernandez, Melanie A. Kimm, Jan Schuemann, Rui Qiu, Bernhard Michalke, Mario A. Bernal, Junli Li, Kerstin Hürkamp, Yibao Zhang, Gabriele Multhoff
Format: article
Langue:EN
Publié: MDPI AG 2021
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Accès en ligne:https://doaj.org/article/873298103d0c414da86571d8be331310
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