Application of High-Z Gold Nanoparticles in Targeted Cancer Radiotherapy—Pharmacokinetic Modeling, Monte Carlo Simulation and Radiobiological Effect Modeling

Application of High-Z Gold Nanoparticles in Targeted Cancer Radiotherapy—Pharmacokinetic Modeling, Monte Carlo Simulation and Radiobiological Effect Modeling

High-Z gold nanoparticles (AuNPs) conjugated to a targeting antibody can help to improve tumor control in radiotherapy while simultaneously minimizing radiotoxicity to adjacent healthy tissue. This paper summarizes the main findings of a joint research program which applied AuNP-conjugates in precli...

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Bibliographic Details
Main Authors: Wei Bo Li, Stefan Stangl, Alexander Klapproth, Maxim Shevtsov, Alicia Hernandez, Melanie A. Kimm, Jan Schuemann, Rui Qiu, Bernhard Michalke, Mario A. Bernal, Junli Li, Kerstin Hürkamp, Yibao Zhang, Gabriele Multhoff
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
cancers
gold nanoparticles
X-rays
cmHsp70.1
conjugation
targeted radiotherapy
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/873298103d0c414da86571d8be331310
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https://doaj.org/article/873298103d0c414da86571d8be331310

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