Electromechanical coupling mechanism for activation and inactivation of an HCN channel

Sea urchin hyperpolarization-activated cyclic nucleotide-gated (spHCN) ion channels channels are activated by membrane hyperpolarization instead of depolarization and undergo inactivation with hyperpolarization. Here authors apply transition metal ion FRET, patch-clamp fluorometry and Rosetta modeli...

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Autores principales:	Gucan Dai, Teresa K. Aman, Frank DiMaio, William N. Zagotta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/87335df92b7c4bdb83eb77f703536c2b
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spelling	oai:doaj.org-article:87335df92b7c4bdb83eb77f703536c2b2021-12-02T15:43:06ZElectromechanical coupling mechanism for activation and inactivation of an HCN channel10.1038/s41467-021-23062-72041-1723https://doaj.org/article/87335df92b7c4bdb83eb77f703536c2b2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23062-7https://doaj.org/toc/2041-1723Sea urchin hyperpolarization-activated cyclic nucleotide-gated (spHCN) ion channels channels are activated by membrane hyperpolarization instead of depolarization and undergo inactivation with hyperpolarization. Here authors apply transition metal ion FRET, patch-clamp fluorometry and Rosetta modeling to measure differences in the structural rearrangements between activation and inactivation of spHCN channels.Gucan DaiTeresa K. AmanFrank DiMaioWilliam N. ZagottaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gucan Dai Teresa K. Aman Frank DiMaio William N. Zagotta Electromechanical coupling mechanism for activation and inactivation of an HCN channel
description	Sea urchin hyperpolarization-activated cyclic nucleotide-gated (spHCN) ion channels channels are activated by membrane hyperpolarization instead of depolarization and undergo inactivation with hyperpolarization. Here authors apply transition metal ion FRET, patch-clamp fluorometry and Rosetta modeling to measure differences in the structural rearrangements between activation and inactivation of spHCN channels.
format	article
author	Gucan Dai Teresa K. Aman Frank DiMaio William N. Zagotta
author_facet	Gucan Dai Teresa K. Aman Frank DiMaio William N. Zagotta
author_sort	Gucan Dai
title	Electromechanical coupling mechanism for activation and inactivation of an HCN channel
title_short	Electromechanical coupling mechanism for activation and inactivation of an HCN channel
title_full	Electromechanical coupling mechanism for activation and inactivation of an HCN channel
title_fullStr	Electromechanical coupling mechanism for activation and inactivation of an HCN channel
title_full_unstemmed	Electromechanical coupling mechanism for activation and inactivation of an HCN channel
title_sort	electromechanical coupling mechanism for activation and inactivation of an hcn channel
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/87335df92b7c4bdb83eb77f703536c2b
work_keys_str_mv	AT gucandai electromechanicalcouplingmechanismforactivationandinactivationofanhcnchannel AT teresakaman electromechanicalcouplingmechanismforactivationandinactivationofanhcnchannel AT frankdimaio electromechanicalcouplingmechanismforactivationandinactivationofanhcnchannel AT williamnzagotta electromechanicalcouplingmechanismforactivationandinactivationofanhcnchannel
_version_	1718385818340425728

Electromechanical coupling mechanism for activation and inactivation of an HCN channel

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