Electromechanical coupling mechanism for activation and inactivation of an HCN channel
Sea urchin hyperpolarization-activated cyclic nucleotide-gated (spHCN) ion channels channels are activated by membrane hyperpolarization instead of depolarization and undergo inactivation with hyperpolarization. Here authors apply transition metal ion FRET, patch-clamp fluorometry and Rosetta modeli...
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Autores principales: | Gucan Dai, Teresa K. Aman, Frank DiMaio, William N. Zagotta |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/87335df92b7c4bdb83eb77f703536c2b |
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