Electromechanical coupling mechanism for activation and inactivation of an HCN channel

Sea urchin hyperpolarization-activated cyclic nucleotide-gated (spHCN) ion channels channels are activated by membrane hyperpolarization instead of depolarization and undergo inactivation with hyperpolarization. Here authors apply transition metal ion FRET, patch-clamp fluorometry and Rosetta modeli...

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Autores principales: Gucan Dai, Teresa K. Aman, Frank DiMaio, William N. Zagotta
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/87335df92b7c4bdb83eb77f703536c2b
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