Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases

Sul-2 is a steroid sulfatase in c.elegans. Here the authors show that, in the absence of sul-2 enzymatic activity, worm lifespan is increased, and that chemical inhibition ameliorates symptoms of neurodegenerative disorders in worms and mice.

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Autores principales:	Mercedes M. Pérez-Jiménez, José M. Monje-Moreno, Ana María Brokate-Llanos, Mónica Venegas-Calerón, Alicia Sánchez-García, Paula Sansigre, Amador Valladares, Sara Esteban-García, Irene Suárez-Pereira, Javier Vitorica, José Julián Ríos, Marta Artal-Sanz, Ángel M. Carrión, Manuel J. Muñoz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/873769f1ad43491084d967f67bef724d
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spelling	oai:doaj.org-article:873769f1ad43491084d967f67bef724d2021-12-02T11:46:01ZSteroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases10.1038/s41467-020-20269-y2041-1723https://doaj.org/article/873769f1ad43491084d967f67bef724d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20269-yhttps://doaj.org/toc/2041-1723Sul-2 is a steroid sulfatase in c.elegans. Here the authors show that, in the absence of sul-2 enzymatic activity, worm lifespan is increased, and that chemical inhibition ameliorates symptoms of neurodegenerative disorders in worms and mice.Mercedes M. Pérez-JiménezJosé M. Monje-MorenoAna María Brokate-LlanosMónica Venegas-CalerónAlicia Sánchez-GarcíaPaula SansigreAmador ValladaresSara Esteban-GarcíaIrene Suárez-PereiraJavier VitoricaJosé Julián RíosMarta Artal-SanzÁngel M. CarriónManuel J. MuñozNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mercedes M. Pérez-Jiménez José M. Monje-Moreno Ana María Brokate-Llanos Mónica Venegas-Calerón Alicia Sánchez-García Paula Sansigre Amador Valladares Sara Esteban-García Irene Suárez-Pereira Javier Vitorica José Julián Ríos Marta Artal-Sanz Ángel M. Carrión Manuel J. Muñoz Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
description	Sul-2 is a steroid sulfatase in c.elegans. Here the authors show that, in the absence of sul-2 enzymatic activity, worm lifespan is increased, and that chemical inhibition ameliorates symptoms of neurodegenerative disorders in worms and mice.
format	article
author	Mercedes M. Pérez-Jiménez José M. Monje-Moreno Ana María Brokate-Llanos Mónica Venegas-Calerón Alicia Sánchez-García Paula Sansigre Amador Valladares Sara Esteban-García Irene Suárez-Pereira Javier Vitorica José Julián Ríos Marta Artal-Sanz Ángel M. Carrión Manuel J. Muñoz
author_facet	Mercedes M. Pérez-Jiménez José M. Monje-Moreno Ana María Brokate-Llanos Mónica Venegas-Calerón Alicia Sánchez-García Paula Sansigre Amador Valladares Sara Esteban-García Irene Suárez-Pereira Javier Vitorica José Julián Ríos Marta Artal-Sanz Ángel M. Carrión Manuel J. Muñoz
author_sort	Mercedes M. Pérez-Jiménez
title	Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
title_short	Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
title_full	Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
title_fullStr	Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
title_full_unstemmed	Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
title_sort	steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/873769f1ad43491084d967f67bef724d
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Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases

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