Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases

Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases

Sul-2 is a steroid sulfatase in c.elegans. Here the authors show that, in the absence of sul-2 enzymatic activity, worm lifespan is increased, and that chemical inhibition ameliorates symptoms of neurodegenerative disorders in worms and mice.

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Bibliographic Details
Main Authors: Mercedes M. Pérez-Jiménez, José M. Monje-Moreno, Ana María Brokate-Llanos, Mónica Venegas-Calerón, Alicia Sánchez-García, Paula Sansigre, Amador Valladares, Sara Esteban-García, Irene Suárez-Pereira, Javier Vitorica, José Julián Ríos, Marta Artal-Sanz, Ángel M. Carrión, Manuel J. Muñoz
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/873769f1ad43491084d967f67bef724d
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https://doaj.org/article/873769f1ad43491084d967f67bef724d

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