Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy

Combination therapy with α-CTLA-4 and α-PD-1 is showing improved therapeutic effects in clinical trials. Here, the authors report that mechanistically in bladder cancer such effect depends upon an upregulation of T cell activity mediated by the IL-7/IL-7R and IFN-γ/IFN-γR signalling pathways.

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Autores principales:	Lewis Zhichang Shi, Tihui Fu, Baoxiang Guan, Jianfeng Chen, Jorge M. Blando, James P. Allison, Liangwen Xiong, Sumit K. Subudhi, Jianjun Gao, Padmanee Sharma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/873bf5f40d50455abd84d3888394defa
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spelling	oai:doaj.org-article:873bf5f40d50455abd84d3888394defa2021-12-02T15:34:56ZInterdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy10.1038/ncomms123352041-1723https://doaj.org/article/873bf5f40d50455abd84d3888394defa2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12335https://doaj.org/toc/2041-1723Combination therapy with α-CTLA-4 and α-PD-1 is showing improved therapeutic effects in clinical trials. Here, the authors report that mechanistically in bladder cancer such effect depends upon an upregulation of T cell activity mediated by the IL-7/IL-7R and IFN-γ/IFN-γR signalling pathways.Lewis Zhichang ShiTihui FuBaoxiang GuanJianfeng ChenJorge M. BlandoJames P. AllisonLiangwen XiongSumit K. SubudhiJianjun GaoPadmanee SharmaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lewis Zhichang Shi Tihui Fu Baoxiang Guan Jianfeng Chen Jorge M. Blando James P. Allison Liangwen Xiong Sumit K. Subudhi Jianjun Gao Padmanee Sharma Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy
description	Combination therapy with α-CTLA-4 and α-PD-1 is showing improved therapeutic effects in clinical trials. Here, the authors report that mechanistically in bladder cancer such effect depends upon an upregulation of T cell activity mediated by the IL-7/IL-7R and IFN-γ/IFN-γR signalling pathways.
format	article
author	Lewis Zhichang Shi Tihui Fu Baoxiang Guan Jianfeng Chen Jorge M. Blando James P. Allison Liangwen Xiong Sumit K. Subudhi Jianjun Gao Padmanee Sharma
author_facet	Lewis Zhichang Shi Tihui Fu Baoxiang Guan Jianfeng Chen Jorge M. Blando James P. Allison Liangwen Xiong Sumit K. Subudhi Jianjun Gao Padmanee Sharma
author_sort	Lewis Zhichang Shi
title	Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy
title_short	Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy
title_full	Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy
title_fullStr	Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy
title_full_unstemmed	Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy
title_sort	interdependent il-7 and ifn-γ signalling in t-cell controls tumour eradication by combined α-ctla-4+α-pd-1 therapy
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/873bf5f40d50455abd84d3888394defa
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Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy

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