NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond

The mechanisms committed in the activation and response of vascular and inflammatory immune cells play a major role in tissue remodeling in cardiovascular diseases (CVDs) such as atherosclerosis, pulmonary arterial hypertension, and abdominal aortic aneurysm. Cardiovascular remodeling entails interr...

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Autores principales:	José Martínez-González, Laia Cañes, Judith Alonso, Carme Ballester-Servera, Antonio Rodríguez-Sinovas, Irene Corrales, Cristina Rodríguez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	NOR-1 cardiovascular remodeling atherosclerosis abdominal aortic aneurysm Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/873edcd594284d43b1a892afebd400c7
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spelling	oai:doaj.org-article:873edcd594284d43b1a892afebd400c72021-11-11T16:50:37ZNR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond10.3390/ijms2221113711422-00671661-6596https://doaj.org/article/873edcd594284d43b1a892afebd400c72021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11371https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The mechanisms committed in the activation and response of vascular and inflammatory immune cells play a major role in tissue remodeling in cardiovascular diseases (CVDs) such as atherosclerosis, pulmonary arterial hypertension, and abdominal aortic aneurysm. Cardiovascular remodeling entails interrelated cellular processes (proliferation, survival/apoptosis, inflammation, extracellular matrix (ECM) synthesis/degradation, redox homeostasis, etc.) coordinately regulated by a reduced number of transcription factors. Nuclear receptors of the subfamily 4 group A (NR4A) have recently emerged as key master genes in multiple cellular processes and vital functions of different organs, and have been involved in a variety of high-incidence human pathologies including atherosclerosis and other CVDs. This paper reviews the major findings involving NR4A3 (Neuron-derived Orphan Receptor 1, NOR-1) in the cardiovascular remodeling operating in these diseases.José Martínez-GonzálezLaia CañesJudith AlonsoCarme Ballester-ServeraAntonio Rodríguez-SinovasIrene CorralesCristina RodríguezMDPI AGarticleNOR-1cardiovascular remodelingatherosclerosisabdominal aortic aneurysmBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11371, p 11371 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NOR-1 cardiovascular remodeling atherosclerosis abdominal aortic aneurysm Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	NOR-1 cardiovascular remodeling atherosclerosis abdominal aortic aneurysm Biology (General) QH301-705.5 Chemistry QD1-999 José Martínez-González Laia Cañes Judith Alonso Carme Ballester-Servera Antonio Rodríguez-Sinovas Irene Corrales Cristina Rodríguez NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond
description	The mechanisms committed in the activation and response of vascular and inflammatory immune cells play a major role in tissue remodeling in cardiovascular diseases (CVDs) such as atherosclerosis, pulmonary arterial hypertension, and abdominal aortic aneurysm. Cardiovascular remodeling entails interrelated cellular processes (proliferation, survival/apoptosis, inflammation, extracellular matrix (ECM) synthesis/degradation, redox homeostasis, etc.) coordinately regulated by a reduced number of transcription factors. Nuclear receptors of the subfamily 4 group A (NR4A) have recently emerged as key master genes in multiple cellular processes and vital functions of different organs, and have been involved in a variety of high-incidence human pathologies including atherosclerosis and other CVDs. This paper reviews the major findings involving NR4A3 (Neuron-derived Orphan Receptor 1, NOR-1) in the cardiovascular remodeling operating in these diseases.
format	article
author	José Martínez-González Laia Cañes Judith Alonso Carme Ballester-Servera Antonio Rodríguez-Sinovas Irene Corrales Cristina Rodríguez
author_facet	José Martínez-González Laia Cañes Judith Alonso Carme Ballester-Servera Antonio Rodríguez-Sinovas Irene Corrales Cristina Rodríguez
author_sort	José Martínez-González
title	NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond
title_short	NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond
title_full	NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond
title_fullStr	NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond
title_full_unstemmed	NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond
title_sort	nr4a3: a key nuclear receptor in vascular biology, cardiovascular remodeling, and beyond
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/873edcd594284d43b1a892afebd400c7
work_keys_str_mv	AT josemartinezgonzalez nr4a3akeynuclearreceptorinvascularbiologycardiovascularremodelingandbeyond AT laiacanes nr4a3akeynuclearreceptorinvascularbiologycardiovascularremodelingandbeyond AT judithalonso nr4a3akeynuclearreceptorinvascularbiologycardiovascularremodelingandbeyond AT carmeballesterservera nr4a3akeynuclearreceptorinvascularbiologycardiovascularremodelingandbeyond AT antoniorodriguezsinovas nr4a3akeynuclearreceptorinvascularbiologycardiovascularremodelingandbeyond AT irenecorrales nr4a3akeynuclearreceptorinvascularbiologycardiovascularremodelingandbeyond AT cristinarodriguez nr4a3akeynuclearreceptorinvascularbiologycardiovascularremodelingandbeyond
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NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond

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