Antiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian Patients

HIV-1 infection keeps on being a global problem because of its pandemic character and the impossibility for eradication. The combined antiretroviral therapy (АRТ) remains the only treatment which has proven its effectiveness for maintaining the life of HIV positive patients. Because of long term (li...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Stojanova Yancheva Nina
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2015
Materias:	hiv art combined antiretroviral therapy laboratory parameters Medicine R
Acceso en línea:	https://doaj.org/article/8743d924370d4eb880ef86b835fa6698
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8743d924370d4eb880ef86b835fa6698
record_format	dspace
spelling	oai:doaj.org-article:8743d924370d4eb880ef86b835fa66982021-12-02T16:42:08ZAntiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian Patients0324-175010.1515/amb-2015-0012https://doaj.org/article/8743d924370d4eb880ef86b835fa66982015-11-01T00:00:00Zhttps://doi.org/10.1515/amb-2015-0012https://doaj.org/toc/0324-1750HIV-1 infection keeps on being a global problem because of its pandemic character and the impossibility for eradication. The combined antiretroviral therapy (АRТ) remains the only treatment which has proven its effectiveness for maintaining the life of HIV positive patients. Because of long term (life time) duration of this therapy, it is necessary to monitor patients for possible drug toxicity. The aim of our research is to evaluate the changes of basic laboratory examinations while conducting a long-term АRТ. We analyzed basic laboratory studies of 145 HIV-infected Bulgarian patients in the current research. The patients were separated into four groups according to their treatment regimen. They were on dispensary monitoring and were being treated in the Department for Patients with Acquired Immune Deficiency in the Specialized Hospital for Active Treatment of Infectious and Parasitic Diseases “Prof. Ivan Kirov” - Sofia. Our results showed that combined ART led to changes in blood count, alanin-aminotransferase (ALT), glucose and total cholesterol. Some of these changes are significant for some of the drugs administered. The current ART does not lead to severe toxicity and life-threatening conditions such as those which were observed in the first few years of ART introduction.Stojanova Yancheva NinaSciendoarticlehivartcombined antiretroviral therapylaboratory parametersMedicineRENActa Medica Bulgarica, Vol 42, Iss 2, Pp 5-15 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	hiv art combined antiretroviral therapy laboratory parameters Medicine R
spellingShingle	hiv art combined antiretroviral therapy laboratory parameters Medicine R Stojanova Yancheva Nina Antiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian Patients
description	HIV-1 infection keeps on being a global problem because of its pandemic character and the impossibility for eradication. The combined antiretroviral therapy (АRТ) remains the only treatment which has proven its effectiveness for maintaining the life of HIV positive patients. Because of long term (life time) duration of this therapy, it is necessary to monitor patients for possible drug toxicity. The aim of our research is to evaluate the changes of basic laboratory examinations while conducting a long-term АRТ. We analyzed basic laboratory studies of 145 HIV-infected Bulgarian patients in the current research. The patients were separated into four groups according to their treatment regimen. They were on dispensary monitoring and were being treated in the Department for Patients with Acquired Immune Deficiency in the Specialized Hospital for Active Treatment of Infectious and Parasitic Diseases “Prof. Ivan Kirov” - Sofia. Our results showed that combined ART led to changes in blood count, alanin-aminotransferase (ALT), glucose and total cholesterol. Some of these changes are significant for some of the drugs administered. The current ART does not lead to severe toxicity and life-threatening conditions such as those which were observed in the first few years of ART introduction.
format	article
author	Stojanova Yancheva Nina
author_facet	Stojanova Yancheva Nina
author_sort	Stojanova Yancheva Nina
title	Antiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian Patients
title_short	Antiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian Patients
title_full	Antiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian Patients
title_fullStr	Antiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian Patients
title_full_unstemmed	Antiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian Patients
title_sort	antiretroviral therapy – changes of basic laboratory parameters in hiv-infected bulgarian patients
publisher	Sciendo
publishDate	2015
url	https://doaj.org/article/8743d924370d4eb880ef86b835fa6698
work_keys_str_mv	AT stojanovayanchevanina antiretroviraltherapychangesofbasiclaboratoryparametersinhivinfectedbulgarianpatients
_version_	1718383583888932864

Antiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian Patients

Ejemplares similares