Tofacitinib Ameliorates Retinal Vascular Leakage in a Murine Model of Diabetic Retinopathy with Type 2 Diabetes

Código QR

Tofacitinib Ameliorates Retinal Vascular Leakage in a Murine Model of Diabetic Retinopathy with Type 2 Diabetes

We have previously reported that inhibition of the Janus kinase 1 (JAK1) signaling ameliorates IL-17A-mediated blood-retinal barrier (BRB) dysfunction. Higher levels of IL-17A have been observed in the blood and intraocular fluids in patients with diabetic retinopathy (DR), in particular those with...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eimear M. Byrne, María Llorián-Salvador, Timothy J. Lyons, Mei Chen, Heping Xu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	JAK1 diabetes JAK/STAT retina inflammation macular edema Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/87449f3a925a48d2b1438066aeb4b0e7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Edaravone alleviates cell apoptosis and mitochondrial injury in ischemia-reperfusion-induced kidney injury via the JAK/STAT pathway
por: Zhao,Xiaoying, et al.
Publicado: (2020)

Janus Kinase Inhibitors in the Treatment of Vitiligo: A Review
por: Fei Qi, et al.
Publicado: (2021)

JQ-1 ameliorates schistosomiasis liver fibrosis by suppressing JAK2 and STAT3 activation
por: Han Ding, et al.
Publicado: (2021)

Corrigendum: ErHuang Formula Improves Renal Fibrosis in Diabetic Nephropathy Rats by Inhibiting CXCL6/JAK/STAT3 Signaling Pathway
por: Yu-Li Shen, et al.
Publicado: (2021)

CXCL8(3-72) K11R/G31P protects against sepsis-induced acute kidney injury via NF-κB and JAK2/STAT3 pathway
por: Zhou,Yunfeng, et al.
Publicado: (2019)

Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats
por: Hafez,Mohamed M, et al.
Publicado: (2015)

STAT6 EXPRESSION BY PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA
por: V. N. Mineev, et al.
Publicado: (2014)

Overexpression of E3 ubiquitin ligase Cbl attenuates endothelial dysfunction in diabetes mellitus by inhibiting the JAK2/STAT4 signaling and Runx3-mediated H3K4me3
por: Qingsong Jin, et al.
Publicado: (2021)

Safety of anti-VEGF treatments in a diabetic rat model and retinal cell culture
por: Filek R, et al.
Publicado: (2019)

Murine Oncostatin M Has Opposing Effects on the Proliferation of OP9 Bone Marrow Stromal Cells and NIH/3T3 Fibroblasts Signaling through the OSMR
por: Lena Jakob, et al.
Publicado: (2021)

EFFECTS OF IL-4 UPON THE ACTIVITY OF STAT6 TRANSCRIPTION FACTOR IN PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA
por: V. N. Mineev, et al.
Publicado: (2014)

Expression analysis of protein inhibitor of activated STAT (PIAS) genes in IFNβ-treated multiple sclerosis patients
por: Taheri M, et al.
Publicado: (2018)

Activated Natural Killer Cell Promotes Nonalcoholic Steatohepatitis Through Mediating JAK/STAT PathwaySummary
por: Feixue Wang, et al.
Publicado: (2022)

Tofacitinib effectiveness in Blau syndrome: a case series of Chinese paediatric patients
por: Song Zhang, et al.
Publicado: (2021)

The Evolving Treatment of Diabetic Retinopathy
por: Mansour SE, et al.
Publicado: (2020)

Quantitative Proteome Analysis of <italic toggle="yes">Atg5</italic>-Deficient Mouse Embryonic Fibroblasts Reveals the Range of the Autophagy-Modulated Basal Cellular Proteome
por: Kiran Bala Sharma, et al.
Publicado: (2019)

Overexpression of miR125b Promotes Osteoporosis Through miR-125b-TRAF6 Pathway in Postmenopausal Ovariectomized Rats
por: Wang G, et al.
Publicado: (2021)

Green synthesis of gold nanoparticles using Euphrasia officinalis leaf extract to inhibit lipopolysaccharide-induced inflammation through NF-κB and JAK/STAT pathways in RAW 264.7 macrophages
por: Liu Y, et al.
Publicado: (2019)

Bridging Radiotherapy to Immunotherapy: The IFN–JAK–STAT Axis
por: Lewis Zhichang Shi, et al.
Publicado: (2021)

Two-year analysis of changes in the optic nerve and retina following anti-VEGF treatments in diabetic macular edema patients
por: Filek R, et al.
Publicado: (2019)

Cordycepin Attenuates Immune Function Injury in A Rat Model of Lung Cancer After Radiotherapy by Inhibiting JAK2/STAT3 Pathway
por: LIU Jianbo, et al.
Publicado: (2021)

Dysregulation of DPP4 Is Associated with the AMPK/JAK2/STAT3 Pathway in Adipocytes Under Insulin Resistance Status and Liraglutide Intervention
por: Cheng F, et al.
Publicado: (2019)

Effect of oral tranexamic acid on macular edema associated with retinal vein occlusion or diabetes
por: Takeyama M, et al.
Publicado: (2017)

IL6R inhibits viability and apoptosis of pancreatic beta-cells in type 2 diabetes mellitus via regulation by miR-22 of the JAK/STAT signaling pathway
por: Wu X, et al.
Publicado: (2019)

Therapeutic effects of an innovative BS-HH-002 drug on pancreatic cancer cells via induction of complete MCL-1 degradation
por: A-min Wang, et al.
Publicado: (2022)

Photobiomodulation Therapy for Age-Related Macular Degeneration and Diabetic Retinopathy: A Review
por: Muste JC, et al.
Publicado: (2021)

Effects of Intravitreal Bevacizumab Therapy in Patients with Proliferative Diabetic Retinopathy
por: Ribeiro de Carvalho G, et al.
Publicado: (2020)

Identifying Diabetic Macular Edema and Other Retinal Diseases by Optical Coherence Tomography Image and Multiscale Deep Learning
por: Zhang Q, et al.
Publicado: (2020)

Iridin Prevented Against Lipopolysaccharide-Induced Inflammatory Responses of Macrophages via Inactivation of PKM2-Mediated Glycolytic Pathways
por: Ying ZH, et al.
Publicado: (2021)

Nifuroxazide Mitigates Angiogenesis in Ehlrich’s Solid Carcinoma: Molecular Docking, Bioinformatic and Experimental Studies on Inhibition of Il-6/Jak2/Stat3 Signaling
por: Mohamed El-Sherbiny, et al.
Publicado: (2021)

Taxus wallichiana var. chinensis (Pilg.) Florin Aqueous Extract Suppresses the Proliferation and Metastasis in Lung Carcinoma via JAK/STAT3 Signaling Pathway
por: Leitao Sun, et al.
Publicado: (2021)

Hyperleptinemia results in systemic inflammation and the exacerbation of ischemia-reperfusion myocardial injury
por: Ekaterina A. Polyakova, et al.
Publicado: (2021)

Photobiomodulation inhibits the activation of neurotoxic microglia and astrocytes by inhibiting Lcn2/JAK2-STAT3 crosstalk after spinal cord injury in male rats
por: Xuankang Wang, et al.
Publicado: (2021)

Diabetic Population-Based Model to Estimate Impact of Ranibizumab on Diabetic Retinopathy Severity in Patients with Diabetic Macular Edema
por: Varma R, et al.
Publicado: (2020)

Macular oedema as manifestation of diabetic retinopathy
por: Mukharram M. Bikbov, et al.
Publicado: (2017)

Impact of injection therapy on retinal patients with diabetic macular edema or retinal vein occlusion
por: Hall J
Publicado: (2016)

Biomarkers for diabetic retinopathy
por: Maria V. Budzinskaya, et al.
Publicado: (2020)

Baricitinib: The First Jak Inhibitor Approved in Europe for the Treatment of Moderate to Severe Atopic Dermatitis in Adult Patients
por: Giulia Radi, et al.
Publicado: (2021)

Evaluating the Safety, Efficacy, and Therapeutic Potential of Momelotinib in the Treatment of Intermediate/High-Risk Myelofibrosis: Evidence to Date
por: Bassiony S, et al.
Publicado: (2020)

ADVANCED THERAPY IN PATIENTS WITH PRIMARY AND POSTPOLYCYTHEMIC MYELOFIBROSIS
por: A. N. Alekseeva, et al.
Publicado: (2017)