Keratopathy, cataract, and dry eye in a survey of aniridia subjects

David Shiple,1 Brenton Finklea,1 James D Lauderdale,2 Peter A Netland1 1Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA; 2Department of Cellular Biology, University of Georgia, Athens, GA, USA Purpose: To determine the prevalence of keratopathy, ca...

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Autores principales:	Shiple D, Finklea B, Lauderdale JD, Netl, PA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/874851aa1bf1409fa6c71806f0dbdc33
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spelling	oai:doaj.org-article:874851aa1bf1409fa6c71806f0dbdc332021-12-02T01:48:10ZKeratopathy, cataract, and dry eye in a survey of aniridia subjects1177-5483https://doaj.org/article/874851aa1bf1409fa6c71806f0dbdc332015-02-01T00:00:00Zhttp://www.dovepress.com/keratopathy-cataract-and-dry-eye-in-a-survey-of-aniridia-subjects-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 David Shiple,1 Brenton Finklea,1 James D Lauderdale,2 Peter A Netland1 1Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA; 2Department of Cellular Biology, University of Georgia, Athens, GA, USA Purpose: To determine the prevalence of keratopathy, cataract, and dry eye in a group of individuals with aniridia. Methods: We reviewed survey data from the Aniridia Foundation International (AFI) registry, which included 99 subjects who self-reported on corneal disease, cataract, and dry eye disease. Results: The average age of respondents was 25.3±18.6 years, with a range of 0 to 67. Of 99 subjects, 46% stated they have corneal disease, 32% stated they did not, and 22% were unsure. The average age of diagnosis of keratopathy was 20.0±12.2 years. Keratolimbal allograft was reported in 20% and penetrating keratoplasty in 9%. Cataract was reported in 65%, with an average age of 9.4±14.0 years at time of diagnosis, and cataract surgery was reported in 32%. The average age of subjects at the time of cataract and corneal surgery was 28.4±13.7 and 33.5±11.4 years, respectively. Symptomatic dry eye was reported in 56% of subjects, with an average age at diagnosis of 23.8±13.3 years. Conclusion: There is a high prevalence of corneal disease in aniridia, with diagnosis in late childhood or early adulthood in nearly one-half of subjects, often requiring corneal surgery. Cataract and dry eye are commonly associated with aniridia. Although aniridia subjects may have been aware of the diagnosis of cataract at an early age, they usually were treated for cataract and keratopathy as adults. Keywords: aniridic keratopathy, ocular surface disease, corneal disease, keratolimbal allograftShiple DFinklea BLauderdale JDNetlPADove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 291-295 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Shiple D Finklea B Lauderdale JD Netl PA Keratopathy, cataract, and dry eye in a survey of aniridia subjects
description	David Shiple,1 Brenton Finklea,1 James D Lauderdale,2 Peter A Netland1 1Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA; 2Department of Cellular Biology, University of Georgia, Athens, GA, USA Purpose: To determine the prevalence of keratopathy, cataract, and dry eye in a group of individuals with aniridia. Methods: We reviewed survey data from the Aniridia Foundation International (AFI) registry, which included 99 subjects who self-reported on corneal disease, cataract, and dry eye disease. Results: The average age of respondents was 25.3±18.6 years, with a range of 0 to 67. Of 99 subjects, 46% stated they have corneal disease, 32% stated they did not, and 22% were unsure. The average age of diagnosis of keratopathy was 20.0±12.2 years. Keratolimbal allograft was reported in 20% and penetrating keratoplasty in 9%. Cataract was reported in 65%, with an average age of 9.4±14.0 years at time of diagnosis, and cataract surgery was reported in 32%. The average age of subjects at the time of cataract and corneal surgery was 28.4±13.7 and 33.5±11.4 years, respectively. Symptomatic dry eye was reported in 56% of subjects, with an average age at diagnosis of 23.8±13.3 years. Conclusion: There is a high prevalence of corneal disease in aniridia, with diagnosis in late childhood or early adulthood in nearly one-half of subjects, often requiring corneal surgery. Cataract and dry eye are commonly associated with aniridia. Although aniridia subjects may have been aware of the diagnosis of cataract at an early age, they usually were treated for cataract and keratopathy as adults. Keywords: aniridic keratopathy, ocular surface disease, corneal disease, keratolimbal allograft
format	article
author	Shiple D Finklea B Lauderdale JD Netl PA
author_facet	Shiple D Finklea B Lauderdale JD Netl PA
author_sort	Shiple D
title	Keratopathy, cataract, and dry eye in a survey of aniridia subjects
title_short	Keratopathy, cataract, and dry eye in a survey of aniridia subjects
title_full	Keratopathy, cataract, and dry eye in a survey of aniridia subjects
title_fullStr	Keratopathy, cataract, and dry eye in a survey of aniridia subjects
title_full_unstemmed	Keratopathy, cataract, and dry eye in a survey of aniridia subjects
title_sort	keratopathy, cataract, and dry eye in a survey of aniridia subjects
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/874851aa1bf1409fa6c71806f0dbdc33
work_keys_str_mv	AT shipled keratopathycataractanddryeyeinasurveyofaniridiasubjects AT finkleab keratopathycataractanddryeyeinasurveyofaniridiasubjects AT lauderdalejd keratopathycataractanddryeyeinasurveyofaniridiasubjects AT netl keratopathycataractanddryeyeinasurveyofaniridiasubjects AT pa keratopathycataractanddryeyeinasurveyofaniridiasubjects
_version_	1718402904802459648

Keratopathy, cataract, and dry eye in a survey of aniridia subjects

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