Imbalanced oxidative stress causes chlamydial persistence during non-productive human herpes virus co-infection.

Both human herpes viruses and Chlamydia are highly prevalent in the human population and are detected together in different human disorders. Here, we demonstrate that co-infection with human herpes virus 6 (HHV6) interferes with the developmental cycle of C. trachomatis and induces persistence. Indu...

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Autores principales:	Bhupesh K Prusty, Linda Böhme, Birgit Bergmann, Christine Siegl, Eva Krause, Adrian Mehlitz, Thomas Rudel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/874c4ed8e3a54ad3aeeaaf2f594ec268
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spelling	oai:doaj.org-article:874c4ed8e3a54ad3aeeaaf2f594ec2682021-11-18T08:11:58ZImbalanced oxidative stress causes chlamydial persistence during non-productive human herpes virus co-infection.1932-620310.1371/journal.pone.0047427https://doaj.org/article/874c4ed8e3a54ad3aeeaaf2f594ec2682012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23077614/?tool=EBIhttps://doaj.org/toc/1932-6203Both human herpes viruses and Chlamydia are highly prevalent in the human population and are detected together in different human disorders. Here, we demonstrate that co-infection with human herpes virus 6 (HHV6) interferes with the developmental cycle of C. trachomatis and induces persistence. Induction of chlamydial persistence by HHV6 is independent of productive virus infection, but requires the interaction and uptake of the virus by the host cell. On the other hand, viral uptake is strongly promoted under co-infection conditions. Host cell glutathione reductase activity was suppressed by HHV6 causing NADPH accumulation, decreased formation of reduced glutathione and increased oxidative stress. Prevention of oxidative stress restored infectivity of Chlamydia after HHV6-induced persistence. We show that co-infection with Herpes simplex virus 1 or human Cytomegalovirus also induces chlamydial persistence by a similar mechanism suggesting that Chlamydia -human herpes virus co-infections are evolutionary shaped interactions with a thus far unrecognized broad significance.Bhupesh K PrustyLinda BöhmeBirgit BergmannChristine SieglEva KrauseAdrian MehlitzThomas RudelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e47427 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bhupesh K Prusty Linda Böhme Birgit Bergmann Christine Siegl Eva Krause Adrian Mehlitz Thomas Rudel Imbalanced oxidative stress causes chlamydial persistence during non-productive human herpes virus co-infection.
description	Both human herpes viruses and Chlamydia are highly prevalent in the human population and are detected together in different human disorders. Here, we demonstrate that co-infection with human herpes virus 6 (HHV6) interferes with the developmental cycle of C. trachomatis and induces persistence. Induction of chlamydial persistence by HHV6 is independent of productive virus infection, but requires the interaction and uptake of the virus by the host cell. On the other hand, viral uptake is strongly promoted under co-infection conditions. Host cell glutathione reductase activity was suppressed by HHV6 causing NADPH accumulation, decreased formation of reduced glutathione and increased oxidative stress. Prevention of oxidative stress restored infectivity of Chlamydia after HHV6-induced persistence. We show that co-infection with Herpes simplex virus 1 or human Cytomegalovirus also induces chlamydial persistence by a similar mechanism suggesting that Chlamydia -human herpes virus co-infections are evolutionary shaped interactions with a thus far unrecognized broad significance.
format	article
author	Bhupesh K Prusty Linda Böhme Birgit Bergmann Christine Siegl Eva Krause Adrian Mehlitz Thomas Rudel
author_facet	Bhupesh K Prusty Linda Böhme Birgit Bergmann Christine Siegl Eva Krause Adrian Mehlitz Thomas Rudel
author_sort	Bhupesh K Prusty
title	Imbalanced oxidative stress causes chlamydial persistence during non-productive human herpes virus co-infection.
title_short	Imbalanced oxidative stress causes chlamydial persistence during non-productive human herpes virus co-infection.
title_full	Imbalanced oxidative stress causes chlamydial persistence during non-productive human herpes virus co-infection.
title_fullStr	Imbalanced oxidative stress causes chlamydial persistence during non-productive human herpes virus co-infection.
title_full_unstemmed	Imbalanced oxidative stress causes chlamydial persistence during non-productive human herpes virus co-infection.
title_sort	imbalanced oxidative stress causes chlamydial persistence during non-productive human herpes virus co-infection.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/874c4ed8e3a54ad3aeeaaf2f594ec268
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Imbalanced oxidative stress causes chlamydial persistence during non-productive human herpes virus co-infection.

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