Association of hemodynamic factors and progressive aortic dilatation following type A aortic dissection surgical repair

Abstract Type A aortic dissection (TAAD) involves the ascending aorta or the arch. Acute TAAD usually requires urgent replacement of the ascending aorta. However, a subset of these patients develops aortic rupture due to further dilatation of the residual dissected aorta. There is currently no relia...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yu Zhu, Saeed Mirsadraee, George Asimakopoulos, Alessia Gambaro, Ulrich Rosendahl, John Pepper, Xiao Yun Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/874c9fdfa8ba47969473f1c7f0e3c0f0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:874c9fdfa8ba47969473f1c7f0e3c0f0
record_format	dspace
spelling	oai:doaj.org-article:874c9fdfa8ba47969473f1c7f0e3c0f02021-12-02T18:24:53ZAssociation of hemodynamic factors and progressive aortic dilatation following type A aortic dissection surgical repair10.1038/s41598-021-91079-52045-2322https://doaj.org/article/874c9fdfa8ba47969473f1c7f0e3c0f02021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91079-5https://doaj.org/toc/2045-2322Abstract Type A aortic dissection (TAAD) involves the ascending aorta or the arch. Acute TAAD usually requires urgent replacement of the ascending aorta. However, a subset of these patients develops aortic rupture due to further dilatation of the residual dissected aorta. There is currently no reliable means to predict the risk of dilatation following TAAD repair. In this study, we performed a comprehensive morphological and hemodynamic analysis for patients with and without progressive aortic dilatation following surgical replacement of the ascending aorta. Patient-specific models of repaired TAAD were reconstructed from post-surgery computed tomography images for detailed computational fluid dynamic analysis. Geometric and hemodynamic parameters were evaluated and compared between patients with stable aortic diameters (N = 9) and those with aortic dilatation (N = 8). Our results showed that the number of re-entry tears and true/false lumen pressure difference were significantly different between the two groups. Patients with progressive aortic dilatation had higher luminal pressure difference (6.7 [4.6, 10.9] vs. 0.9 [0.5, 2.3] mmHg; P = 0.001) and fewer re-entry tears (1.5 [1, 2.8] vs. 5 [3.3, 7.5]; P = 0.02) compared to patients with stable aortic diameters, suggesting that these factors may serve as potential predictors of aneurysmal dilatation following surgical repair of TAAD.Yu ZhuSaeed MirsadraeeGeorge AsimakopoulosAlessia GambaroUlrich RosendahlJohn PepperXiao Yun XuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu Zhu Saeed Mirsadraee George Asimakopoulos Alessia Gambaro Ulrich Rosendahl John Pepper Xiao Yun Xu Association of hemodynamic factors and progressive aortic dilatation following type A aortic dissection surgical repair
description	Abstract Type A aortic dissection (TAAD) involves the ascending aorta or the arch. Acute TAAD usually requires urgent replacement of the ascending aorta. However, a subset of these patients develops aortic rupture due to further dilatation of the residual dissected aorta. There is currently no reliable means to predict the risk of dilatation following TAAD repair. In this study, we performed a comprehensive morphological and hemodynamic analysis for patients with and without progressive aortic dilatation following surgical replacement of the ascending aorta. Patient-specific models of repaired TAAD were reconstructed from post-surgery computed tomography images for detailed computational fluid dynamic analysis. Geometric and hemodynamic parameters were evaluated and compared between patients with stable aortic diameters (N = 9) and those with aortic dilatation (N = 8). Our results showed that the number of re-entry tears and true/false lumen pressure difference were significantly different between the two groups. Patients with progressive aortic dilatation had higher luminal pressure difference (6.7 [4.6, 10.9] vs. 0.9 [0.5, 2.3] mmHg; P = 0.001) and fewer re-entry tears (1.5 [1, 2.8] vs. 5 [3.3, 7.5]; P = 0.02) compared to patients with stable aortic diameters, suggesting that these factors may serve as potential predictors of aneurysmal dilatation following surgical repair of TAAD.
format	article
author	Yu Zhu Saeed Mirsadraee George Asimakopoulos Alessia Gambaro Ulrich Rosendahl John Pepper Xiao Yun Xu
author_facet	Yu Zhu Saeed Mirsadraee George Asimakopoulos Alessia Gambaro Ulrich Rosendahl John Pepper Xiao Yun Xu
author_sort	Yu Zhu
title	Association of hemodynamic factors and progressive aortic dilatation following type A aortic dissection surgical repair
title_short	Association of hemodynamic factors and progressive aortic dilatation following type A aortic dissection surgical repair
title_full	Association of hemodynamic factors and progressive aortic dilatation following type A aortic dissection surgical repair
title_fullStr	Association of hemodynamic factors and progressive aortic dilatation following type A aortic dissection surgical repair
title_full_unstemmed	Association of hemodynamic factors and progressive aortic dilatation following type A aortic dissection surgical repair
title_sort	association of hemodynamic factors and progressive aortic dilatation following type a aortic dissection surgical repair
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/874c9fdfa8ba47969473f1c7f0e3c0f0
work_keys_str_mv	AT yuzhu associationofhemodynamicfactorsandprogressiveaorticdilatationfollowingtypeaaorticdissectionsurgicalrepair AT saeedmirsadraee associationofhemodynamicfactorsandprogressiveaorticdilatationfollowingtypeaaorticdissectionsurgicalrepair AT georgeasimakopoulos associationofhemodynamicfactorsandprogressiveaorticdilatationfollowingtypeaaorticdissectionsurgicalrepair AT alessiagambaro associationofhemodynamicfactorsandprogressiveaorticdilatationfollowingtypeaaorticdissectionsurgicalrepair AT ulrichrosendahl associationofhemodynamicfactorsandprogressiveaorticdilatationfollowingtypeaaorticdissectionsurgicalrepair AT johnpepper associationofhemodynamicfactorsandprogressiveaorticdilatationfollowingtypeaaorticdissectionsurgicalrepair AT xiaoyunxu associationofhemodynamicfactorsandprogressiveaorticdilatationfollowingtypeaaorticdissectionsurgicalrepair
_version_	1718378106871349248

Association of hemodynamic factors and progressive aortic dilatation following type A aortic dissection surgical repair

Ejemplares similares