Ultrasounds could be considered as a future tool for probing growing bone properties

Abstract Juvenile bone growth is well described (physiological and anatomical) but there are still lacks of knowledge on intrinsic material properties. Our group has already published, on different samples, several studies on the assessment of intrinsic material properties of juvenile bone compared...

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Autores principales:	Emmanuelle Lefevre, Cécile Baron, Evelyne Gineyts, Yohann Bala, Hakim Gharbi, Jean-Marc Allain, Philippe Lasaygues, Martine Pithioux, Hélène Follet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8754148bd96943828eb141e20d29f622
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spelling	oai:doaj.org-article:8754148bd96943828eb141e20d29f6222021-12-02T18:48:22ZUltrasounds could be considered as a future tool for probing growing bone properties10.1038/s41598-020-72776-z2045-2322https://doaj.org/article/8754148bd96943828eb141e20d29f6222020-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-72776-zhttps://doaj.org/toc/2045-2322Abstract Juvenile bone growth is well described (physiological and anatomical) but there are still lacks of knowledge on intrinsic material properties. Our group has already published, on different samples, several studies on the assessment of intrinsic material properties of juvenile bone compared to material properties of adult bone. The purpose of this study was finally to combine different experimental modalities available (ultrasonic measurement, micro-Computed Tomography analysis, mechanical compression tests and biochemical measurements) applied on small cubic bone samples in order to gain insight into the multiparametric evaluation of bone quality. Differences were found between juvenile and adult groups in term of architectural parameters (Porosity Separation), Tissue Mineral Density (TMD), diagonal stiffness coefficients (C33, C44, C55, C66) and ratio between immature and mature cross-links (CX). Diagonal stiffness coefficients are more representative of the microstructural and biochemical parameters of child bone than of adult bone. We also found that compression modulus E was highly correlated with several microstructure parameters and CX in children group while it was not at all correlated in the adult group. Similar results were found for the CX which was linked to several microstructure parameters (TMD and E) only in the juvenile group. To our knowledge, this is the first time that, on a same sample, ultrasonic measurements have been combined with the assessment of mechanical and biochemical properties. It appears that ultrasonic measurements can provide relevant indicators of child bone quality (microstructural and biochemical parameters) which is promising for clinical application since, B-mode ultrasound is the preferred first-line modality over other more constraining imaging modalities (radiation, parent–child accessibility and access to the patient's bed) for pediatric patients.Emmanuelle LefevreCécile BaronEvelyne GineytsYohann BalaHakim GharbiJean-Marc AllainPhilippe LasayguesMartine PithiouxHélène FolletNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emmanuelle Lefevre Cécile Baron Evelyne Gineyts Yohann Bala Hakim Gharbi Jean-Marc Allain Philippe Lasaygues Martine Pithioux Hélène Follet Ultrasounds could be considered as a future tool for probing growing bone properties
description	Abstract Juvenile bone growth is well described (physiological and anatomical) but there are still lacks of knowledge on intrinsic material properties. Our group has already published, on different samples, several studies on the assessment of intrinsic material properties of juvenile bone compared to material properties of adult bone. The purpose of this study was finally to combine different experimental modalities available (ultrasonic measurement, micro-Computed Tomography analysis, mechanical compression tests and biochemical measurements) applied on small cubic bone samples in order to gain insight into the multiparametric evaluation of bone quality. Differences were found between juvenile and adult groups in term of architectural parameters (Porosity Separation), Tissue Mineral Density (TMD), diagonal stiffness coefficients (C33, C44, C55, C66) and ratio between immature and mature cross-links (CX). Diagonal stiffness coefficients are more representative of the microstructural and biochemical parameters of child bone than of adult bone. We also found that compression modulus E was highly correlated with several microstructure parameters and CX in children group while it was not at all correlated in the adult group. Similar results were found for the CX which was linked to several microstructure parameters (TMD and E) only in the juvenile group. To our knowledge, this is the first time that, on a same sample, ultrasonic measurements have been combined with the assessment of mechanical and biochemical properties. It appears that ultrasonic measurements can provide relevant indicators of child bone quality (microstructural and biochemical parameters) which is promising for clinical application since, B-mode ultrasound is the preferred first-line modality over other more constraining imaging modalities (radiation, parent–child accessibility and access to the patient's bed) for pediatric patients.
format	article
author	Emmanuelle Lefevre Cécile Baron Evelyne Gineyts Yohann Bala Hakim Gharbi Jean-Marc Allain Philippe Lasaygues Martine Pithioux Hélène Follet
author_facet	Emmanuelle Lefevre Cécile Baron Evelyne Gineyts Yohann Bala Hakim Gharbi Jean-Marc Allain Philippe Lasaygues Martine Pithioux Hélène Follet
author_sort	Emmanuelle Lefevre
title	Ultrasounds could be considered as a future tool for probing growing bone properties
title_short	Ultrasounds could be considered as a future tool for probing growing bone properties
title_full	Ultrasounds could be considered as a future tool for probing growing bone properties
title_fullStr	Ultrasounds could be considered as a future tool for probing growing bone properties
title_full_unstemmed	Ultrasounds could be considered as a future tool for probing growing bone properties
title_sort	ultrasounds could be considered as a future tool for probing growing bone properties
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8754148bd96943828eb141e20d29f622
work_keys_str_mv	AT emmanuellelefevre ultrasoundscouldbeconsideredasafuturetoolforprobinggrowingboneproperties AT cecilebaron ultrasoundscouldbeconsideredasafuturetoolforprobinggrowingboneproperties AT evelynegineyts ultrasoundscouldbeconsideredasafuturetoolforprobinggrowingboneproperties AT yohannbala ultrasoundscouldbeconsideredasafuturetoolforprobinggrowingboneproperties AT hakimgharbi ultrasoundscouldbeconsideredasafuturetoolforprobinggrowingboneproperties AT jeanmarcallain ultrasoundscouldbeconsideredasafuturetoolforprobinggrowingboneproperties AT philippelasaygues ultrasoundscouldbeconsideredasafuturetoolforprobinggrowingboneproperties AT martinepithioux ultrasoundscouldbeconsideredasafuturetoolforprobinggrowingboneproperties AT helenefollet ultrasoundscouldbeconsideredasafuturetoolforprobinggrowingboneproperties
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Ultrasounds could be considered as a future tool for probing growing bone properties

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