Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank

Abstract Here, we investigated the genetics of weighted functional brain network graph theory measures from 18,445 participants of the UK Biobank (44–80 years). The eighteen measures studied showed low heritability (mean h2 SNP = 0.12) and were highly genetically correlated. One genome-wide signific...

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Autores principales:	Heidi Foo, Anbupalam Thalamuthu, Jiyang Jiang, Forrest C. Koch, Karen A. Mather, Wei Wen, Perminder S. Sachdev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/875432f0d03d497b994988390a3d9116
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spelling	oai:doaj.org-article:875432f0d03d497b994988390a3d91162021-12-02T18:30:57ZNovel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank10.1038/s41598-021-94182-92045-2322https://doaj.org/article/875432f0d03d497b994988390a3d91162021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94182-9https://doaj.org/toc/2045-2322Abstract Here, we investigated the genetics of weighted functional brain network graph theory measures from 18,445 participants of the UK Biobank (44–80 years). The eighteen measures studied showed low heritability (mean h2 SNP = 0.12) and were highly genetically correlated. One genome-wide significant locus was associated with strength of somatomotor and limbic networks. These intergenic variants were located near the PAX8 gene on chromosome 2. Gene-based analyses identified five significantly associated genes for five of the network measures, which have been implicated in sleep duration, neuronal differentiation/development, cancer, and susceptibility to neurodegenerative diseases. Further analysis found that somatomotor network strength was phenotypically associated with sleep duration and insomnia. Single nucleotide polymorphism (SNP) and gene level associations with functional network measures were identified, which may help uncover novel biological pathways relevant to human brain functional network integrity and related disorders that affect it.Heidi FooAnbupalam ThalamuthuJiyang JiangForrest C. KochKaren A. MatherWei WenPerminder S. SachdevNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Heidi Foo Anbupalam Thalamuthu Jiyang Jiang Forrest C. Koch Karen A. Mather Wei Wen Perminder S. Sachdev Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank
description	Abstract Here, we investigated the genetics of weighted functional brain network graph theory measures from 18,445 participants of the UK Biobank (44–80 years). The eighteen measures studied showed low heritability (mean h2 SNP = 0.12) and were highly genetically correlated. One genome-wide significant locus was associated with strength of somatomotor and limbic networks. These intergenic variants were located near the PAX8 gene on chromosome 2. Gene-based analyses identified five significantly associated genes for five of the network measures, which have been implicated in sleep duration, neuronal differentiation/development, cancer, and susceptibility to neurodegenerative diseases. Further analysis found that somatomotor network strength was phenotypically associated with sleep duration and insomnia. Single nucleotide polymorphism (SNP) and gene level associations with functional network measures were identified, which may help uncover novel biological pathways relevant to human brain functional network integrity and related disorders that affect it.
format	article
author	Heidi Foo Anbupalam Thalamuthu Jiyang Jiang Forrest C. Koch Karen A. Mather Wei Wen Perminder S. Sachdev
author_facet	Heidi Foo Anbupalam Thalamuthu Jiyang Jiang Forrest C. Koch Karen A. Mather Wei Wen Perminder S. Sachdev
author_sort	Heidi Foo
title	Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank
title_short	Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank
title_full	Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank
title_fullStr	Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank
title_full_unstemmed	Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank
title_sort	novel genetic variants associated with brain functional networks in 18,445 adults from the uk biobank
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/875432f0d03d497b994988390a3d9116
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Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank

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