Sex-dependent effects of forced exercise in the body composition of adolescent rats

Abstract Determining the body composition during adolescence can predict diseases such as obesity, diabetes, and metabolic syndromes later in life; and physical activity became an effective way to restore changes in body composition. However, current available literature assessing the body compositi...

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Autores principales:	Y. Kutsenko, A. Barreda, A. Toval, D. Garrigos, M. Martínez-Morga, B. Ribeiro Do Couto, J. L. Ferran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8759e42fc4d84ece9dd2befeb008cb09
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spelling	oai:doaj.org-article:8759e42fc4d84ece9dd2befeb008cb092021-12-02T16:50:37ZSex-dependent effects of forced exercise in the body composition of adolescent rats10.1038/s41598-021-89584-82045-2322https://doaj.org/article/8759e42fc4d84ece9dd2befeb008cb092021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89584-8https://doaj.org/toc/2045-2322Abstract Determining the body composition during adolescence can predict diseases such as obesity, diabetes, and metabolic syndromes later in life; and physical activity became an effective way to restore changes in body composition. However, current available literature assessing the body composition before, during and after adolescence in female and male rodents by in vivo techniques is scarce. Thus, by using computerized tomography, we aimed to define the baseline of the weight and body composition during the adolescence and young adulthood of female and male Sprague–Dawley rats (on P30, P60 and P90) under standard diet. Then, we determined the effect of 18 days of forced exercise on the body weight and composition during the early adolescence (P27-45). The highest percentual increments in weight, body volume and relative adipose contents occurred during the female and male adolescence. Forced running during the early adolescence decreased weight, body volume and relative adipose delta and increment values in males only. The adolescence of rats is a period of drastic body composition changes, where exercise interventions have sex-dependent effects. These results support a model that could open new research windows in the field of adolescent obesity.Y. KutsenkoA. BarredaA. TovalD. GarrigosM. Martínez-MorgaB. Ribeiro Do CoutoJ. L. FerranNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Y. Kutsenko A. Barreda A. Toval D. Garrigos M. Martínez-Morga B. Ribeiro Do Couto J. L. Ferran Sex-dependent effects of forced exercise in the body composition of adolescent rats
description	Abstract Determining the body composition during adolescence can predict diseases such as obesity, diabetes, and metabolic syndromes later in life; and physical activity became an effective way to restore changes in body composition. However, current available literature assessing the body composition before, during and after adolescence in female and male rodents by in vivo techniques is scarce. Thus, by using computerized tomography, we aimed to define the baseline of the weight and body composition during the adolescence and young adulthood of female and male Sprague–Dawley rats (on P30, P60 and P90) under standard diet. Then, we determined the effect of 18 days of forced exercise on the body weight and composition during the early adolescence (P27-45). The highest percentual increments in weight, body volume and relative adipose contents occurred during the female and male adolescence. Forced running during the early adolescence decreased weight, body volume and relative adipose delta and increment values in males only. The adolescence of rats is a period of drastic body composition changes, where exercise interventions have sex-dependent effects. These results support a model that could open new research windows in the field of adolescent obesity.
format	article
author	Y. Kutsenko A. Barreda A. Toval D. Garrigos M. Martínez-Morga B. Ribeiro Do Couto J. L. Ferran
author_facet	Y. Kutsenko A. Barreda A. Toval D. Garrigos M. Martínez-Morga B. Ribeiro Do Couto J. L. Ferran
author_sort	Y. Kutsenko
title	Sex-dependent effects of forced exercise in the body composition of adolescent rats
title_short	Sex-dependent effects of forced exercise in the body composition of adolescent rats
title_full	Sex-dependent effects of forced exercise in the body composition of adolescent rats
title_fullStr	Sex-dependent effects of forced exercise in the body composition of adolescent rats
title_full_unstemmed	Sex-dependent effects of forced exercise in the body composition of adolescent rats
title_sort	sex-dependent effects of forced exercise in the body composition of adolescent rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8759e42fc4d84ece9dd2befeb008cb09
work_keys_str_mv	AT ykutsenko sexdependenteffectsofforcedexerciseinthebodycompositionofadolescentrats AT abarreda sexdependenteffectsofforcedexerciseinthebodycompositionofadolescentrats AT atoval sexdependenteffectsofforcedexerciseinthebodycompositionofadolescentrats AT dgarrigos sexdependenteffectsofforcedexerciseinthebodycompositionofadolescentrats AT mmartinezmorga sexdependenteffectsofforcedexerciseinthebodycompositionofadolescentrats AT bribeirodocouto sexdependenteffectsofforcedexerciseinthebodycompositionofadolescentrats AT jlferran sexdependenteffectsofforcedexerciseinthebodycompositionofadolescentrats
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Sex-dependent effects of forced exercise in the body composition of adolescent rats

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