Astronauts well-being and possibly anti-aging improved during long-duration spaceflight

Abstract This study assesses how circadian rhythms of heart rate (HR), HR variability (HRV) and activity change during long-term missions in space and how they relate to sleep quality. Ambulatory 48-h ECG and 96-h actigraphy were performed four times on ten healthy astronauts (44.7 ± 6.9 years; 9 me...

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Autores principales:	Kuniaki Otsuka, Germaine Cornelissen, Satoshi Furukawa, Yutaka Kubo, Koichi Shibata, Koh Mizuno, Hiroshi Ohshima, Chiaki Mukai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/875b6252a5c941e9b8ca8224884e5cbd
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spelling	oai:doaj.org-article:875b6252a5c941e9b8ca8224884e5cbd2021-12-02T16:26:23ZAstronauts well-being and possibly anti-aging improved during long-duration spaceflight10.1038/s41598-021-94478-w2045-2322https://doaj.org/article/875b6252a5c941e9b8ca8224884e5cbd2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94478-whttps://doaj.org/toc/2045-2322Abstract This study assesses how circadian rhythms of heart rate (HR), HR variability (HRV) and activity change during long-term missions in space and how they relate to sleep quality. Ambulatory 48-h ECG and 96-h actigraphy were performed four times on ten healthy astronauts (44.7 ± 6.9 years; 9 men): 120.4 ± 43.7 days (Before) launch; 21.1 ± 2.5 days (ISS01) and 143.0 ± 27.1 days (ISS02) after launch; and 86.6 ± 40.6 days (After) return to Earth. Sleep quality was determined by sleep-related changes in activity, RR-intervals, HRV HF- and VLF-components and LF-band. The circadian amplitude of HR (HR-A) was larger in space (ISS01: 12.54, P = 0.0099; ISS02: 12.77, P = 0.0364) than on Earth (Before: 10.90; After: 10.55 bpm). Sleep duration in space (ISS01/ISS02) increased in 3 (Group A, from 370.7 to 388.0/413.0 min) and decreased in 7 (Group B, from 454.0 to 408.9/381.6 min) astronauts. Sleep quality improved in Group B from 7.07 to 8.36 (ISS01) and 9.36 (ISS02, P = 0.0001). Sleep-related parasympathetic activity increased from 55.2% to 74.8% (pNN50, P = 0.0010) (ISS02). HR-A correlated with the 24-h (r = 0.8110, P = 0.0044), 12-h (r = 0.6963, P = 0.0253), and 48-h (r = 0.6921, P = 0.0266) amplitudes of the magnetic declination index. These findings suggest associations of mission duration with increased well-being and anti-aging benefitting from magnetic fluctuations.Kuniaki OtsukaGermaine CornelissenSatoshi FurukawaYutaka KuboKoichi ShibataKoh MizunoHiroshi OhshimaChiaki MukaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kuniaki Otsuka Germaine Cornelissen Satoshi Furukawa Yutaka Kubo Koichi Shibata Koh Mizuno Hiroshi Ohshima Chiaki Mukai Astronauts well-being and possibly anti-aging improved during long-duration spaceflight
description	Abstract This study assesses how circadian rhythms of heart rate (HR), HR variability (HRV) and activity change during long-term missions in space and how they relate to sleep quality. Ambulatory 48-h ECG and 96-h actigraphy were performed four times on ten healthy astronauts (44.7 ± 6.9 years; 9 men): 120.4 ± 43.7 days (Before) launch; 21.1 ± 2.5 days (ISS01) and 143.0 ± 27.1 days (ISS02) after launch; and 86.6 ± 40.6 days (After) return to Earth. Sleep quality was determined by sleep-related changes in activity, RR-intervals, HRV HF- and VLF-components and LF-band. The circadian amplitude of HR (HR-A) was larger in space (ISS01: 12.54, P = 0.0099; ISS02: 12.77, P = 0.0364) than on Earth (Before: 10.90; After: 10.55 bpm). Sleep duration in space (ISS01/ISS02) increased in 3 (Group A, from 370.7 to 388.0/413.0 min) and decreased in 7 (Group B, from 454.0 to 408.9/381.6 min) astronauts. Sleep quality improved in Group B from 7.07 to 8.36 (ISS01) and 9.36 (ISS02, P = 0.0001). Sleep-related parasympathetic activity increased from 55.2% to 74.8% (pNN50, P = 0.0010) (ISS02). HR-A correlated with the 24-h (r = 0.8110, P = 0.0044), 12-h (r = 0.6963, P = 0.0253), and 48-h (r = 0.6921, P = 0.0266) amplitudes of the magnetic declination index. These findings suggest associations of mission duration with increased well-being and anti-aging benefitting from magnetic fluctuations.
format	article
author	Kuniaki Otsuka Germaine Cornelissen Satoshi Furukawa Yutaka Kubo Koichi Shibata Koh Mizuno Hiroshi Ohshima Chiaki Mukai
author_facet	Kuniaki Otsuka Germaine Cornelissen Satoshi Furukawa Yutaka Kubo Koichi Shibata Koh Mizuno Hiroshi Ohshima Chiaki Mukai
author_sort	Kuniaki Otsuka
title	Astronauts well-being and possibly anti-aging improved during long-duration spaceflight
title_short	Astronauts well-being and possibly anti-aging improved during long-duration spaceflight
title_full	Astronauts well-being and possibly anti-aging improved during long-duration spaceflight
title_fullStr	Astronauts well-being and possibly anti-aging improved during long-duration spaceflight
title_full_unstemmed	Astronauts well-being and possibly anti-aging improved during long-duration spaceflight
title_sort	astronauts well-being and possibly anti-aging improved during long-duration spaceflight
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/875b6252a5c941e9b8ca8224884e5cbd
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Astronauts well-being and possibly anti-aging improved during long-duration spaceflight

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