INTERRELATIONS BETWEEN NEUTRO PHIL ENZYMES AND THEIR INHIBITORS IN PATHOGENESIS OF ACUTE RESPIRATORY DISTRESS SYNDROME ASSOCIATED WITH INFLUENZA PNEUMONIA

Abstract. Amounts of several neutrophil enzymes (elastase, myeloperoxidase (MPO), MMP-2) and their local inhibitors, i.e., Clara cell protein (CC16) and HSP-70, have been determined in blood plasma from fifty-two patients with various forms of influenza A/H1N1. Sixteen patients have developed acute...

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Autores principales:	E. V. Prutkina, N. N. Tsybikov, N. V. Isakova, A. V. Sepp
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	neutrophil enzymes clara cell protein hsp-70 acute respiratory distress syndrome influenza a/h1n1 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/875eca944f3448a6bd3cfceaccb13524
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spelling	oai:doaj.org-article:875eca944f3448a6bd3cfceaccb135242021-11-18T08:03:40ZINTERRELATIONS BETWEEN NEUTRO PHIL ENZYMES AND THEIR INHIBITORS IN PATHOGENESIS OF ACUTE RESPIRATORY DISTRESS SYNDROME ASSOCIATED WITH INFLUENZA PNEUMONIA1563-06252313-741X10.15789/1563-0625-2012-3-227-232https://doaj.org/article/875eca944f3448a6bd3cfceaccb135242014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/359https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Amounts of several neutrophil enzymes (elastase, myeloperoxidase (MPO), MMP-2) and their local inhibitors, i.e., Clara cell protein (CC16) and HSP-70, have been determined in blood plasma from fifty-two patients with various forms of influenza A/H1N1. Sixteen patients have developed acute respiratory distress syndrome (ARDS). In cases of uncomplicated influenza, elastase and MPO levels were shown to be increased, while MMP-2 levels did not change, along with higher contents of HSP-70 and unchanged CC16 amounts. Upon development of influenza-associated pneumonia, elastase and MPO concentrations became elevated, whereas MMP-2 levels were decreased, along with unchanged amounts of CC16 and HSP-70. In cases of ARDS development, CC16 amounts exhibited a sharp decrease. Meanwhile, contents of other proteins remained at the levels shown for pneumonia patients. It has been shown that increased concentrations of neutrophil elastase and MPO with a relative CC16 deficiency and decreased MMP-2 may represent a mechanism of pneumonia development. Decreased CC16 concentration may serve as a risk predictor of ARDS development.E. V. PrutkinaN. N. TsybikovN. V. IsakovaA. V. SeppSPb RAACIarticleneutrophil enzymesclara cell proteinhsp-70acute respiratory distress syndromeinfluenza a/h1n1Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 3, Pp 227-232 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	neutrophil enzymes clara cell protein hsp-70 acute respiratory distress syndrome influenza a/h1n1 Immunologic diseases. Allergy RC581-607
spellingShingle	neutrophil enzymes clara cell protein hsp-70 acute respiratory distress syndrome influenza a/h1n1 Immunologic diseases. Allergy RC581-607 E. V. Prutkina N. N. Tsybikov N. V. Isakova A. V. Sepp INTERRELATIONS BETWEEN NEUTRO PHIL ENZYMES AND THEIR INHIBITORS IN PATHOGENESIS OF ACUTE RESPIRATORY DISTRESS SYNDROME ASSOCIATED WITH INFLUENZA PNEUMONIA
description	Abstract. Amounts of several neutrophil enzymes (elastase, myeloperoxidase (MPO), MMP-2) and their local inhibitors, i.e., Clara cell protein (CC16) and HSP-70, have been determined in blood plasma from fifty-two patients with various forms of influenza A/H1N1. Sixteen patients have developed acute respiratory distress syndrome (ARDS). In cases of uncomplicated influenza, elastase and MPO levels were shown to be increased, while MMP-2 levels did not change, along with higher contents of HSP-70 and unchanged CC16 amounts. Upon development of influenza-associated pneumonia, elastase and MPO concentrations became elevated, whereas MMP-2 levels were decreased, along with unchanged amounts of CC16 and HSP-70. In cases of ARDS development, CC16 amounts exhibited a sharp decrease. Meanwhile, contents of other proteins remained at the levels shown for pneumonia patients. It has been shown that increased concentrations of neutrophil elastase and MPO with a relative CC16 deficiency and decreased MMP-2 may represent a mechanism of pneumonia development. Decreased CC16 concentration may serve as a risk predictor of ARDS development.
format	article
author	E. V. Prutkina N. N. Tsybikov N. V. Isakova A. V. Sepp
author_facet	E. V. Prutkina N. N. Tsybikov N. V. Isakova A. V. Sepp
author_sort	E. V. Prutkina
title	INTERRELATIONS BETWEEN NEUTRO PHIL ENZYMES AND THEIR INHIBITORS IN PATHOGENESIS OF ACUTE RESPIRATORY DISTRESS SYNDROME ASSOCIATED WITH INFLUENZA PNEUMONIA
title_short	INTERRELATIONS BETWEEN NEUTRO PHIL ENZYMES AND THEIR INHIBITORS IN PATHOGENESIS OF ACUTE RESPIRATORY DISTRESS SYNDROME ASSOCIATED WITH INFLUENZA PNEUMONIA
title_full	INTERRELATIONS BETWEEN NEUTRO PHIL ENZYMES AND THEIR INHIBITORS IN PATHOGENESIS OF ACUTE RESPIRATORY DISTRESS SYNDROME ASSOCIATED WITH INFLUENZA PNEUMONIA
title_fullStr	INTERRELATIONS BETWEEN NEUTRO PHIL ENZYMES AND THEIR INHIBITORS IN PATHOGENESIS OF ACUTE RESPIRATORY DISTRESS SYNDROME ASSOCIATED WITH INFLUENZA PNEUMONIA
title_full_unstemmed	INTERRELATIONS BETWEEN NEUTRO PHIL ENZYMES AND THEIR INHIBITORS IN PATHOGENESIS OF ACUTE RESPIRATORY DISTRESS SYNDROME ASSOCIATED WITH INFLUENZA PNEUMONIA
title_sort	interrelations between neutro phil enzymes and their inhibitors in pathogenesis of acute respiratory distress syndrome associated with influenza pneumonia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/875eca944f3448a6bd3cfceaccb13524
work_keys_str_mv	AT evprutkina interrelationsbetweenneutrophilenzymesandtheirinhibitorsinpathogenesisofacuterespiratorydistresssyndromeassociatedwithinfluenzapneumonia AT nntsybikov interrelationsbetweenneutrophilenzymesandtheirinhibitorsinpathogenesisofacuterespiratorydistresssyndromeassociatedwithinfluenzapneumonia AT nvisakova interrelationsbetweenneutrophilenzymesandtheirinhibitorsinpathogenesisofacuterespiratorydistresssyndromeassociatedwithinfluenzapneumonia AT avsepp interrelationsbetweenneutrophilenzymesandtheirinhibitorsinpathogenesisofacuterespiratorydistresssyndromeassociatedwithinfluenzapneumonia
_version_	1718422489645711360

INTERRELATIONS BETWEEN NEUTRO PHIL ENZYMES AND THEIR INHIBITORS IN PATHOGENESIS OF ACUTE RESPIRATORY DISTRESS SYNDROME ASSOCIATED WITH INFLUENZA PNEUMONIA

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