A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance

Dysregulation of insulin secretion dynamics plays a role in diabetes development. Here, the authors build a mathematical model of hepatic insulin signaling and propose a sequential model of post-meal control of glucose and lipids, according to which delayed aPKC suppression would contribute to selec...

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Autores principales:	Gang Zhao, Dagmar Wirth, Ingo Schmitz, Michael Meyer-Hermann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/875f7f23aee6420fbea12103dcd5e61f
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spelling	oai:doaj.org-article:875f7f23aee6420fbea12103dcd5e61f2021-12-02T17:06:02ZA mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance10.1038/s41467-017-01627-92041-1723https://doaj.org/article/875f7f23aee6420fbea12103dcd5e61f2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01627-9https://doaj.org/toc/2041-1723Dysregulation of insulin secretion dynamics plays a role in diabetes development. Here, the authors build a mathematical model of hepatic insulin signaling and propose a sequential model of post-meal control of glucose and lipids, according to which delayed aPKC suppression would contribute to selective hepatic insulin resistance.Gang ZhaoDagmar WirthIngo SchmitzMichael Meyer-HermannNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gang Zhao Dagmar Wirth Ingo Schmitz Michael Meyer-Hermann A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance
description	Dysregulation of insulin secretion dynamics plays a role in diabetes development. Here, the authors build a mathematical model of hepatic insulin signaling and propose a sequential model of post-meal control of glucose and lipids, according to which delayed aPKC suppression would contribute to selective hepatic insulin resistance.
format	article
author	Gang Zhao Dagmar Wirth Ingo Schmitz Michael Meyer-Hermann
author_facet	Gang Zhao Dagmar Wirth Ingo Schmitz Michael Meyer-Hermann
author_sort	Gang Zhao
title	A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance
title_short	A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance
title_full	A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance
title_fullStr	A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance
title_full_unstemmed	A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance
title_sort	mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/875f7f23aee6420fbea12103dcd5e61f
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A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance

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