A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance

Dysregulation of insulin secretion dynamics plays a role in diabetes development. Here, the authors build a mathematical model of hepatic insulin signaling and propose a sequential model of post-meal control of glucose and lipids, according to which delayed aPKC suppression would contribute to selec...

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Autores principales: Gang Zhao, Dagmar Wirth, Ingo Schmitz, Michael Meyer-Hermann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/875f7f23aee6420fbea12103dcd5e61f
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