A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance
Dysregulation of insulin secretion dynamics plays a role in diabetes development. Here, the authors build a mathematical model of hepatic insulin signaling and propose a sequential model of post-meal control of glucose and lipids, according to which delayed aPKC suppression would contribute to selec...
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Autores principales: | Gang Zhao, Dagmar Wirth, Ingo Schmitz, Michael Meyer-Hermann |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/875f7f23aee6420fbea12103dcd5e61f |
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