Shielding and activation of a viral membrane fusion protein

Viral fusion proteins undergo extensive conformational changes during entry but intermediate conformations often remain unknown. Here, the authors show how Gn of Rift Valley fever virus fusion protein shields hydrophobic fusion loops of Gc and how these loops embed in the target membrane at acidic c...

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Autores principales:	Steinar Halldorsson, Sai Li, Mengqiu Li, Karl Harlos, Thomas A. Bowden, Juha T. Huiskonen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/875fd015c6954da8bc20cc2adff407bf
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spelling	oai:doaj.org-article:875fd015c6954da8bc20cc2adff407bf2021-12-02T16:49:31ZShielding and activation of a viral membrane fusion protein10.1038/s41467-017-02789-22041-1723https://doaj.org/article/875fd015c6954da8bc20cc2adff407bf2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02789-2https://doaj.org/toc/2041-1723Viral fusion proteins undergo extensive conformational changes during entry but intermediate conformations often remain unknown. Here, the authors show how Gn of Rift Valley fever virus fusion protein shields hydrophobic fusion loops of Gc and how these loops embed in the target membrane at acidic conditions.Steinar HalldorssonSai LiMengqiu LiKarl HarlosThomas A. BowdenJuha T. HuiskonenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Steinar Halldorsson Sai Li Mengqiu Li Karl Harlos Thomas A. Bowden Juha T. Huiskonen Shielding and activation of a viral membrane fusion protein
description	Viral fusion proteins undergo extensive conformational changes during entry but intermediate conformations often remain unknown. Here, the authors show how Gn of Rift Valley fever virus fusion protein shields hydrophobic fusion loops of Gc and how these loops embed in the target membrane at acidic conditions.
format	article
author	Steinar Halldorsson Sai Li Mengqiu Li Karl Harlos Thomas A. Bowden Juha T. Huiskonen
author_facet	Steinar Halldorsson Sai Li Mengqiu Li Karl Harlos Thomas A. Bowden Juha T. Huiskonen
author_sort	Steinar Halldorsson
title	Shielding and activation of a viral membrane fusion protein
title_short	Shielding and activation of a viral membrane fusion protein
title_full	Shielding and activation of a viral membrane fusion protein
title_fullStr	Shielding and activation of a viral membrane fusion protein
title_full_unstemmed	Shielding and activation of a viral membrane fusion protein
title_sort	shielding and activation of a viral membrane fusion protein
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/875fd015c6954da8bc20cc2adff407bf
work_keys_str_mv	AT steinarhalldorsson shieldingandactivationofaviralmembranefusionprotein AT saili shieldingandactivationofaviralmembranefusionprotein AT mengqiuli shieldingandactivationofaviralmembranefusionprotein AT karlharlos shieldingandactivationofaviralmembranefusionprotein AT thomasabowden shieldingandactivationofaviralmembranefusionprotein AT juhathuiskonen shieldingandactivationofaviralmembranefusionprotein
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Shielding and activation of a viral membrane fusion protein

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