Synthetic Biology-Based Approaches for Microalgal Bio-Removal of Heavy Metals From Wastewater Effluents

Heavy metal polluted wastewater from industries is currently one of the major environmental concerns leading to insufficient supply of clean water. Several strategies have been implemented to overcome this challenge including the use of microalgae as heavy metal bio-removers. However, there are stil...

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Autores principales:	Pachara Sattayawat, Ian S. Yunus, Nuttapol Noirungsee, Nilita Mukjang, Wasu Pathom-Aree, Jeeraporn Pekkoh, Chayakorn Pumas
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	synthetic biology heavy metal microalgae bio-removal wastewater treament Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/875ff728187546bf92de9619ca65374f
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spelling	oai:doaj.org-article:875ff728187546bf92de9619ca65374f2021-11-30T18:12:34ZSynthetic Biology-Based Approaches for Microalgal Bio-Removal of Heavy Metals From Wastewater Effluents2296-665X10.3389/fenvs.2021.778260https://doaj.org/article/875ff728187546bf92de9619ca65374f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fenvs.2021.778260/fullhttps://doaj.org/toc/2296-665XHeavy metal polluted wastewater from industries is currently one of the major environmental concerns leading to insufficient supply of clean water. Several strategies have been implemented to overcome this challenge including the use of microalgae as heavy metal bio-removers. However, there are still limitations that prevent microalgae to function optimally. Synthetic biology is a new biological discipline developed to solve challenging problems via bioengineering approaches. To date, synthetic biology has no universally affirmed definitions; however, it is uncontroversial that synthetic biology utilizes a constructive library of genetic standardized parts to create new biological systems or to redesign existing ones with improved characteristics. In this mini-review, we present state-of-the-art synthetic biology-based approaches that can be used to enhance heavy metal bio-removal from wastewater effluents by microalgae with a narrative synthetic biology workflow (Design-Build-Test-Learn cycle) to guide future developments of more advanced systems. We also provide insights into potent genes and proteins responsible for the bio-removal processes for stepwise developments of more advanced systems. A total of 49 unique genes and proteins are listed based on their eight heavy metals (Mn, Fe, Cu, Zn, As, Cd, Hg, and Pb) bio-removal functions in transport system, cellular tolerance, synthesis of key players in heavy metal bio-removal, biotransformation of heavy metals, and gene expression regulation. Thus, with our library, genetic parts are ready to be recruited for any synthetic biology-based designs. Thereby, this mini-review identifies potential avenues of future research and maps opportunities to unleash more potential of microalgae as heavy metal bio-removers with synthetic biology.Pachara SattayawatPachara SattayawatPachara SattayawatIan S. YunusIan S. YunusNuttapol NoirungseeNilita MukjangWasu Pathom-AreeJeeraporn PekkohChayakorn PumasFrontiers Media S.A.articlesynthetic biologyheavy metalmicroalgaebio-removalwastewater treamentEnvironmental sciencesGE1-350ENFrontiers in Environmental Science, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	synthetic biology heavy metal microalgae bio-removal wastewater treament Environmental sciences GE1-350
spellingShingle	synthetic biology heavy metal microalgae bio-removal wastewater treament Environmental sciences GE1-350 Pachara Sattayawat Pachara Sattayawat Pachara Sattayawat Ian S. Yunus Ian S. Yunus Nuttapol Noirungsee Nilita Mukjang Wasu Pathom-Aree Jeeraporn Pekkoh Chayakorn Pumas Synthetic Biology-Based Approaches for Microalgal Bio-Removal of Heavy Metals From Wastewater Effluents
description	Heavy metal polluted wastewater from industries is currently one of the major environmental concerns leading to insufficient supply of clean water. Several strategies have been implemented to overcome this challenge including the use of microalgae as heavy metal bio-removers. However, there are still limitations that prevent microalgae to function optimally. Synthetic biology is a new biological discipline developed to solve challenging problems via bioengineering approaches. To date, synthetic biology has no universally affirmed definitions; however, it is uncontroversial that synthetic biology utilizes a constructive library of genetic standardized parts to create new biological systems or to redesign existing ones with improved characteristics. In this mini-review, we present state-of-the-art synthetic biology-based approaches that can be used to enhance heavy metal bio-removal from wastewater effluents by microalgae with a narrative synthetic biology workflow (Design-Build-Test-Learn cycle) to guide future developments of more advanced systems. We also provide insights into potent genes and proteins responsible for the bio-removal processes for stepwise developments of more advanced systems. A total of 49 unique genes and proteins are listed based on their eight heavy metals (Mn, Fe, Cu, Zn, As, Cd, Hg, and Pb) bio-removal functions in transport system, cellular tolerance, synthesis of key players in heavy metal bio-removal, biotransformation of heavy metals, and gene expression regulation. Thus, with our library, genetic parts are ready to be recruited for any synthetic biology-based designs. Thereby, this mini-review identifies potential avenues of future research and maps opportunities to unleash more potential of microalgae as heavy metal bio-removers with synthetic biology.
format	article
author	Pachara Sattayawat Pachara Sattayawat Pachara Sattayawat Ian S. Yunus Ian S. Yunus Nuttapol Noirungsee Nilita Mukjang Wasu Pathom-Aree Jeeraporn Pekkoh Chayakorn Pumas
author_facet	Pachara Sattayawat Pachara Sattayawat Pachara Sattayawat Ian S. Yunus Ian S. Yunus Nuttapol Noirungsee Nilita Mukjang Wasu Pathom-Aree Jeeraporn Pekkoh Chayakorn Pumas
author_sort	Pachara Sattayawat
title	Synthetic Biology-Based Approaches for Microalgal Bio-Removal of Heavy Metals From Wastewater Effluents
title_short	Synthetic Biology-Based Approaches for Microalgal Bio-Removal of Heavy Metals From Wastewater Effluents
title_full	Synthetic Biology-Based Approaches for Microalgal Bio-Removal of Heavy Metals From Wastewater Effluents
title_fullStr	Synthetic Biology-Based Approaches for Microalgal Bio-Removal of Heavy Metals From Wastewater Effluents
title_full_unstemmed	Synthetic Biology-Based Approaches for Microalgal Bio-Removal of Heavy Metals From Wastewater Effluents
title_sort	synthetic biology-based approaches for microalgal bio-removal of heavy metals from wastewater effluents
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/875ff728187546bf92de9619ca65374f
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Synthetic Biology-Based Approaches for Microalgal Bio-Removal of Heavy Metals From Wastewater Effluents

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