The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription.

The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription.

Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from cellular transcripts by a 'cap-snatching' mechanism. Here, we report the crystal structure and functional characterization of the N-terminal 196 residues (NL1) of the L protein from the prototypic arena...

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Bibliographic Details
Main Authors: Benjamin Morin, Bruno Coutard, Michaela Lelke, François Ferron, Romy Kerber, Saïd Jamal, Antoine Frangeul, Cécile Baronti, Rémi Charrel, Xavier de Lamballerie, Clemens Vonrhein, Julien Lescar, Gérard Bricogne, Stephan Günther, Bruno Canard
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2010
Subjects:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/876236fd04814573bef8fd4aed21e9a0
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