Decreased circulating Zinc levels in Parkinson’s disease: a meta-analysis study

Abstract There is no consensus on the involvement of zinc (Zn) dysfunctions in Parkinson’s Disease (PD). We performed a meta-analysis to evaluate whether circulating Zn levels in the serum, plasma, and cerebrospinal fluid (CSF) are altered in PD. Twenty-three published studies were selected by searc...

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Autores principales:	Ke Du, Ming-Yan Liu, Xin Zhong, Min-Jie Wei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/876285c7c3e14886856880b880999dd7
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spelling	oai:doaj.org-article:876285c7c3e14886856880b880999dd72021-12-02T15:05:54ZDecreased circulating Zinc levels in Parkinson’s disease: a meta-analysis study10.1038/s41598-017-04252-02045-2322https://doaj.org/article/876285c7c3e14886856880b880999dd72017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04252-0https://doaj.org/toc/2045-2322Abstract There is no consensus on the involvement of zinc (Zn) dysfunctions in Parkinson’s Disease (PD). We performed a meta-analysis to evaluate whether circulating Zn levels in the serum, plasma, and cerebrospinal fluid (CSF) are altered in PD. Twenty-three published studies were selected by searching the databases of PubMed and China National Knowledge Infrastructure (CNKI). A total of 803 PD patients and 796 controls, 342 PD patients and 392 controls, and 135 PD patients and 93 controls were included to study Zn levels in the serum, plasma, and CSF, respectively. Our meta-analysis showed that the serum Zn levels were significantly lower in PD patients compared with health controls (SMD = −0.59; 95% CI [−1.06, −0.12]; P = 0.014). A reduced Zn levels in PD patients were found when serum and plasma studies were analyzed together (SMD = −0.60, 95% CI [−0.98; −0.22]; p = 0.002). PD patients had a tendency toward reduced CSF Zn levels compared with health controls (SMD = −0.50; 95% CI [−1.76, 0.76]; P = 0.439), but no statistical significance was obtained and this data did not allow conclusions due to a small sample size of CSF studies. This study suggests that reduced Zn levels in the serum and plasma are associated with an increased risk for PD.Ke DuMing-Yan LiuXin ZhongMin-Jie WeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ke Du Ming-Yan Liu Xin Zhong Min-Jie Wei Decreased circulating Zinc levels in Parkinson’s disease: a meta-analysis study
description	Abstract There is no consensus on the involvement of zinc (Zn) dysfunctions in Parkinson’s Disease (PD). We performed a meta-analysis to evaluate whether circulating Zn levels in the serum, plasma, and cerebrospinal fluid (CSF) are altered in PD. Twenty-three published studies were selected by searching the databases of PubMed and China National Knowledge Infrastructure (CNKI). A total of 803 PD patients and 796 controls, 342 PD patients and 392 controls, and 135 PD patients and 93 controls were included to study Zn levels in the serum, plasma, and CSF, respectively. Our meta-analysis showed that the serum Zn levels were significantly lower in PD patients compared with health controls (SMD = −0.59; 95% CI [−1.06, −0.12]; P = 0.014). A reduced Zn levels in PD patients were found when serum and plasma studies were analyzed together (SMD = −0.60, 95% CI [−0.98; −0.22]; p = 0.002). PD patients had a tendency toward reduced CSF Zn levels compared with health controls (SMD = −0.50; 95% CI [−1.76, 0.76]; P = 0.439), but no statistical significance was obtained and this data did not allow conclusions due to a small sample size of CSF studies. This study suggests that reduced Zn levels in the serum and plasma are associated with an increased risk for PD.
format	article
author	Ke Du Ming-Yan Liu Xin Zhong Min-Jie Wei
author_facet	Ke Du Ming-Yan Liu Xin Zhong Min-Jie Wei
author_sort	Ke Du
title	Decreased circulating Zinc levels in Parkinson’s disease: a meta-analysis study
title_short	Decreased circulating Zinc levels in Parkinson’s disease: a meta-analysis study
title_full	Decreased circulating Zinc levels in Parkinson’s disease: a meta-analysis study
title_fullStr	Decreased circulating Zinc levels in Parkinson’s disease: a meta-analysis study
title_full_unstemmed	Decreased circulating Zinc levels in Parkinson’s disease: a meta-analysis study
title_sort	decreased circulating zinc levels in parkinson’s disease: a meta-analysis study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/876285c7c3e14886856880b880999dd7
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Decreased circulating Zinc levels in Parkinson’s disease: a meta-analysis study

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