Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19

Non-human primates are important animal models for studying SARS-CoV-2 infection. Here, Salguero et al. directly compare rhesus and cynomolgus macaques and show that both species represent COVID-19 disease of mild clinical cases, and provide a lung histopathology scoring system.

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Autores principales:	Francisco J. Salguero, Andrew D. White, Gillian S. Slack, Susan A. Fotheringham, Kevin R. Bewley, Karen E. Gooch, Stephanie Longet, Holly E. Humphries, Robert J. Watson, Laura Hunter, Kathryn A. Ryan, Yper Hall, Laura Sibley, Charlotte Sarfas, Lauren Allen, Marilyn Aram, Emily Brunt, Phillip Brown, Karen R. Buttigieg, Breeze E. Cavell, Rebecca Cobb, Naomi S. Coombes, Alistair Darby, Owen Daykin-Pont, Michael J. Elmore, Isabel Garcia-Dorival, Konstantinos Gkolfinos, Kerry J. Godwin, Jade Gouriet, Rachel Halkerston, Debbie J. Harris, Thomas Hender, Catherine M. K. Ho, Chelsea L. Kennard, Daniel Knott, Stephanie Leung, Vanessa Lucas, Adam Mabbutt, Alexandra L. Morrison, Charlotte Nelson, Didier Ngabo, Jemma Paterson, Elizabeth J. Penn, Steve Pullan, Irene Taylor, Tom Tipton, Stephen Thomas, Julia A. Tree, Carrie Turner, Edith Vamos, Nadina Wand, Nathan R. Wiblin, Sue Charlton, Xiaofeng Dong, Bassam Hallis, Geoffrey Pearson, Emma L. Rayner, Andrew G. Nicholson, Simon G. Funnell, Julian A. Hiscox, Mike J. Dennis, Fergus V. Gleeson, Sally Sharpe, Miles W. Carroll
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/87631802f4e34ba091e1f0a793783536
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spelling	oai:doaj.org-article:87631802f4e34ba091e1f0a7937835362021-12-02T13:34:49ZComparison of rhesus and cynomolgus macaques as an infection model for COVID-1910.1038/s41467-021-21389-92041-1723https://doaj.org/article/87631802f4e34ba091e1f0a7937835362021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21389-9https://doaj.org/toc/2041-1723Non-human primates are important animal models for studying SARS-CoV-2 infection. Here, Salguero et al. directly compare rhesus and cynomolgus macaques and show that both species represent COVID-19 disease of mild clinical cases, and provide a lung histopathology scoring system.Francisco J. SalgueroAndrew D. WhiteGillian S. SlackSusan A. FotheringhamKevin R. BewleyKaren E. GoochStephanie LongetHolly E. HumphriesRobert J. WatsonLaura HunterKathryn A. RyanYper HallLaura SibleyCharlotte SarfasLauren AllenMarilyn AramEmily BruntPhillip BrownKaren R. ButtigiegBreeze E. CavellRebecca CobbNaomi S. CoombesAlistair DarbyOwen Daykin-PontMichael J. ElmoreIsabel Garcia-DorivalKonstantinos GkolfinosKerry J. GodwinJade GourietRachel HalkerstonDebbie J. HarrisThomas HenderCatherine M. K. HoChelsea L. KennardDaniel KnottStephanie LeungVanessa LucasAdam MabbuttAlexandra L. MorrisonCharlotte NelsonDidier NgaboJemma PatersonElizabeth J. PennSteve PullanIrene TaylorTom TiptonStephen ThomasJulia A. TreeCarrie TurnerEdith VamosNadina WandNathan R. WiblinSue CharltonXiaofeng DongBassam HallisGeoffrey PearsonEmma L. RaynerAndrew G. NicholsonSimon G. FunnellJulian A. HiscoxMike J. DennisFergus V. GleesonSally SharpeMiles W. CarrollNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Francisco J. Salguero Andrew D. White Gillian S. Slack Susan A. Fotheringham Kevin R. Bewley Karen E. Gooch Stephanie Longet Holly E. Humphries Robert J. Watson Laura Hunter Kathryn A. Ryan Yper Hall Laura Sibley Charlotte Sarfas Lauren Allen Marilyn Aram Emily Brunt Phillip Brown Karen R. Buttigieg Breeze E. Cavell Rebecca Cobb Naomi S. Coombes Alistair Darby Owen Daykin-Pont Michael J. Elmore Isabel Garcia-Dorival Konstantinos Gkolfinos Kerry J. Godwin Jade Gouriet Rachel Halkerston Debbie J. Harris Thomas Hender Catherine M. K. Ho Chelsea L. Kennard Daniel Knott Stephanie Leung Vanessa Lucas Adam Mabbutt Alexandra L. Morrison Charlotte Nelson Didier Ngabo Jemma Paterson Elizabeth J. Penn Steve Pullan Irene Taylor Tom Tipton Stephen Thomas Julia A. Tree Carrie Turner Edith Vamos Nadina Wand Nathan R. Wiblin Sue Charlton Xiaofeng Dong Bassam Hallis Geoffrey Pearson Emma L. Rayner Andrew G. Nicholson Simon G. Funnell Julian A. Hiscox Mike J. Dennis Fergus V. Gleeson Sally Sharpe Miles W. Carroll Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
description	Non-human primates are important animal models for studying SARS-CoV-2 infection. Here, Salguero et al. directly compare rhesus and cynomolgus macaques and show that both species represent COVID-19 disease of mild clinical cases, and provide a lung histopathology scoring system.
format	article
author	Francisco J. Salguero Andrew D. White Gillian S. Slack Susan A. Fotheringham Kevin R. Bewley Karen E. Gooch Stephanie Longet Holly E. Humphries Robert J. Watson Laura Hunter Kathryn A. Ryan Yper Hall Laura Sibley Charlotte Sarfas Lauren Allen Marilyn Aram Emily Brunt Phillip Brown Karen R. Buttigieg Breeze E. Cavell Rebecca Cobb Naomi S. Coombes Alistair Darby Owen Daykin-Pont Michael J. Elmore Isabel Garcia-Dorival Konstantinos Gkolfinos Kerry J. Godwin Jade Gouriet Rachel Halkerston Debbie J. Harris Thomas Hender Catherine M. K. Ho Chelsea L. Kennard Daniel Knott Stephanie Leung Vanessa Lucas Adam Mabbutt Alexandra L. Morrison Charlotte Nelson Didier Ngabo Jemma Paterson Elizabeth J. Penn Steve Pullan Irene Taylor Tom Tipton Stephen Thomas Julia A. Tree Carrie Turner Edith Vamos Nadina Wand Nathan R. Wiblin Sue Charlton Xiaofeng Dong Bassam Hallis Geoffrey Pearson Emma L. Rayner Andrew G. Nicholson Simon G. Funnell Julian A. Hiscox Mike J. Dennis Fergus V. Gleeson Sally Sharpe Miles W. Carroll
author_facet	Francisco J. Salguero Andrew D. White Gillian S. Slack Susan A. Fotheringham Kevin R. Bewley Karen E. Gooch Stephanie Longet Holly E. Humphries Robert J. Watson Laura Hunter Kathryn A. Ryan Yper Hall Laura Sibley Charlotte Sarfas Lauren Allen Marilyn Aram Emily Brunt Phillip Brown Karen R. Buttigieg Breeze E. Cavell Rebecca Cobb Naomi S. Coombes Alistair Darby Owen Daykin-Pont Michael J. Elmore Isabel Garcia-Dorival Konstantinos Gkolfinos Kerry J. Godwin Jade Gouriet Rachel Halkerston Debbie J. Harris Thomas Hender Catherine M. K. Ho Chelsea L. Kennard Daniel Knott Stephanie Leung Vanessa Lucas Adam Mabbutt Alexandra L. Morrison Charlotte Nelson Didier Ngabo Jemma Paterson Elizabeth J. Penn Steve Pullan Irene Taylor Tom Tipton Stephen Thomas Julia A. Tree Carrie Turner Edith Vamos Nadina Wand Nathan R. Wiblin Sue Charlton Xiaofeng Dong Bassam Hallis Geoffrey Pearson Emma L. Rayner Andrew G. Nicholson Simon G. Funnell Julian A. Hiscox Mike J. Dennis Fergus V. Gleeson Sally Sharpe Miles W. Carroll
author_sort	Francisco J. Salguero
title	Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
title_short	Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
title_full	Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
title_fullStr	Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
title_full_unstemmed	Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
title_sort	comparison of rhesus and cynomolgus macaques as an infection model for covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/87631802f4e34ba091e1f0a793783536
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Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19

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