E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses
The innate immune response to many RNA viruses depends on recognition of viral RNA by RIG-I. Here the authors show that, upon virus infection, FBXW7 interacts with RIG-I and inhibits ubiquitin-mediated degradation of RIG-I, resulting in increased interferon signallingin vitro and in vivo.
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2017
|
| Subjects: | |
| Online Access: | https://doaj.org/article/8765fcc5c19d48e4bc6d4b98a7ddcbe5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|