Combining Porcine Xenograft Intra-Corneal Ring Segments and CXL: a Novel Technique

Anastasios John Kanellopoulos,1,2 Filippos Vingopoulos1 1Department of Ophthalmology, LaserVision Clinical & Research Eye Institute, Athens, Greece; 2Department of Ophthalmology, New York University Medical School, New York, NY, USACorrespondence: Anastasios John KanellopoulosLaserVision Cli...

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Autores principales:	Kanellopoulos AJ, Vingopoulos F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	intrastromal corneal ring segments gamma radiated porcine cornea bio-logical tissue xenograft corneal surgery myopia correction cornea trans-plantation Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/876820e10e414c738a117b1e23f1ab6b
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spelling	oai:doaj.org-article:876820e10e414c738a117b1e23f1ab6b2021-12-02T05:20:22ZCombining Porcine Xenograft Intra-Corneal Ring Segments and CXL: a Novel Technique1177-5483https://doaj.org/article/876820e10e414c738a117b1e23f1ab6b2019-12-01T00:00:00Zhttps://www.dovepress.com/combining-porcine-xenograft-intra-corneal-ring-segments-and-cxl-a-nove-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Anastasios John Kanellopoulos,1,2 Filippos Vingopoulos1 1Department of Ophthalmology, LaserVision Clinical & Research Eye Institute, Athens, Greece; 2Department of Ophthalmology, New York University Medical School, New York, NY, USACorrespondence: Anastasios John KanellopoulosLaserVision Clinical & Research Eye Institute, Tsocha str. 15 - 17, Athens 115 21, GreeceTel + 30 210 7472777Email ajkmd@mac.comPurpose: The ex-vivo feasibility of creating corneal ring segments (ICRS) from biological tissue (xenograft porcine cornea) and combining intra-corneal implantation with Corneal CrossLinking (CXL).Methods: The ring segments from gamma-irradiated porcine donor cornea were shaped and implanted in human cadaver host cornea using a femtosecond laser for their dissection and host cornea channel preparation. Intra-channel 0.25% riboflavin solution combined with higher fluence CXL of 15 joules total energy followed their implantation. Anterior segment Optical Coherence Tomography (OCT), Scheimpflug tomography and Placido-disc topography were used to monitor the positioning and refractive effect.Results: The novel xenograft ring segments were positioned as planned at 85% corneal depth and mid-peripheral, with documented, up to 7 diopters central cornea flattening.Conclusion: Xenograft intracorneal ring segments combined with CXL may offer an alternative to the synthetic materials used clinically so far, aiming in reducing complications of intracorneal opaque deposit accumulation, segment migration, corneal erosion and potential extrusion. Combining CXL may enhance their refractive effect and stabilize potential or documented host ectasia.Keywords: intrastromal corneal ring segments, gamma-radiated porcine cornea, biological tissue, xenograft corneal surgery, myopia correction, cornea transplantationKanellopoulos AJVingopoulos FDove Medical Pressarticleintrastromal corneal ring segmentsgamma radiated porcine corneabio-logical tissuexenograft corneal surgerymyopia correctioncornea trans-plantationOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 2521-2525 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	intrastromal corneal ring segments gamma radiated porcine cornea bio-logical tissue xenograft corneal surgery myopia correction cornea trans-plantation Ophthalmology RE1-994
spellingShingle	intrastromal corneal ring segments gamma radiated porcine cornea bio-logical tissue xenograft corneal surgery myopia correction cornea trans-plantation Ophthalmology RE1-994 Kanellopoulos AJ Vingopoulos F Combining Porcine Xenograft Intra-Corneal Ring Segments and CXL: a Novel Technique
description	Anastasios John Kanellopoulos,1,2 Filippos Vingopoulos1 1Department of Ophthalmology, LaserVision Clinical & Research Eye Institute, Athens, Greece; 2Department of Ophthalmology, New York University Medical School, New York, NY, USACorrespondence: Anastasios John KanellopoulosLaserVision Clinical & Research Eye Institute, Tsocha str. 15 - 17, Athens 115 21, GreeceTel + 30 210 7472777Email ajkmd@mac.comPurpose: The ex-vivo feasibility of creating corneal ring segments (ICRS) from biological tissue (xenograft porcine cornea) and combining intra-corneal implantation with Corneal CrossLinking (CXL).Methods: The ring segments from gamma-irradiated porcine donor cornea were shaped and implanted in human cadaver host cornea using a femtosecond laser for their dissection and host cornea channel preparation. Intra-channel 0.25% riboflavin solution combined with higher fluence CXL of 15 joules total energy followed their implantation. Anterior segment Optical Coherence Tomography (OCT), Scheimpflug tomography and Placido-disc topography were used to monitor the positioning and refractive effect.Results: The novel xenograft ring segments were positioned as planned at 85% corneal depth and mid-peripheral, with documented, up to 7 diopters central cornea flattening.Conclusion: Xenograft intracorneal ring segments combined with CXL may offer an alternative to the synthetic materials used clinically so far, aiming in reducing complications of intracorneal opaque deposit accumulation, segment migration, corneal erosion and potential extrusion. Combining CXL may enhance their refractive effect and stabilize potential or documented host ectasia.Keywords: intrastromal corneal ring segments, gamma-radiated porcine cornea, biological tissue, xenograft corneal surgery, myopia correction, cornea transplantation
format	article
author	Kanellopoulos AJ Vingopoulos F
author_facet	Kanellopoulos AJ Vingopoulos F
author_sort	Kanellopoulos AJ
title	Combining Porcine Xenograft Intra-Corneal Ring Segments and CXL: a Novel Technique
title_short	Combining Porcine Xenograft Intra-Corneal Ring Segments and CXL: a Novel Technique
title_full	Combining Porcine Xenograft Intra-Corneal Ring Segments and CXL: a Novel Technique
title_fullStr	Combining Porcine Xenograft Intra-Corneal Ring Segments and CXL: a Novel Technique
title_full_unstemmed	Combining Porcine Xenograft Intra-Corneal Ring Segments and CXL: a Novel Technique
title_sort	combining porcine xenograft intra-corneal ring segments and cxl: a novel technique
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/876820e10e414c738a117b1e23f1ab6b
work_keys_str_mv	AT kanellopoulosaj combiningporcinexenograftintracornealringsegmentsandcxlanoveltechnique AT vingopoulosf combiningporcinexenograftintracornealringsegmentsandcxlanoveltechnique
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Combining Porcine Xenograft Intra-Corneal Ring Segments and CXL: a Novel Technique

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