Provocation of symmetry/ordering symptoms in Anorexia nervosa: a functional neuroimaging study.

Anorexia nervosa (AN), obsessive-compulsive disorder (OCD), and obsessive-compulsive personality disorder (OCPD) are often co-morbid; however, the aetiology of such co-morbidity has not been well investigated. This study examined brain activation in women with AN and in healthy control (HC) women du...

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Autores principales:	Masashi Suda, Samantha J Brooks, Vincent Giampietro, Rudolf Uher, David Mataix-Cols, Michael J Brammer, Steven C R Williams, Janet Treasure, Iain C Campbell
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/876b921d948b427bae1d922235a04457
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spelling	oai:doaj.org-article:876b921d948b427bae1d922235a044572021-11-18T08:18:38ZProvocation of symmetry/ordering symptoms in Anorexia nervosa: a functional neuroimaging study.1932-620310.1371/journal.pone.0097998https://doaj.org/article/876b921d948b427bae1d922235a044572014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24844926/?tool=EBIhttps://doaj.org/toc/1932-6203Anorexia nervosa (AN), obsessive-compulsive disorder (OCD), and obsessive-compulsive personality disorder (OCPD) are often co-morbid; however, the aetiology of such co-morbidity has not been well investigated. This study examined brain activation in women with AN and in healthy control (HC) women during the provocation of symmetry/ordering-related anxiety. During provocation, patients with AN showed more anxiety compared to HCs, which was correlated with the severity of symmetry/ordering symptoms. Activation in the right parietal lobe and right prefrontal cortex (rPFC) in response to provocation was reduced in the AN group compared with the HC group. The reduced right parietal activation observed in the AN group is consistent with parietal lobe involvement in visuospatial cognition and with studies of OCD reporting an association between structural abnormalities in this region and the severity of 'ordering' symptoms. Reduced rPFC activation in response to symmetry/ordering provocation has similarities with some, but not all, data collected from patients with AN who were exposed to images of food and bodies. Furthermore, the combination of data from the AN and HC groups showed that rPFC activation during symptom provocation was inversely correlated with the severity of symmetry/ordering symptoms. These data suggest that individuals with AN have a diminished ability to cognitively deal with illness-associated symptoms of provocation. Furthermore, our data also suggest that symptom provocation can progressively overload attempts by the rPFC to exert cognitive control. These findings are discussed in the context of the current neurobiological models of AN.Masashi SudaSamantha J BrooksVincent GiampietroRudolf UherDavid Mataix-ColsMichael J BrammerSteven C R WilliamsJanet TreasureIain C CampbellPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e97998 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masashi Suda Samantha J Brooks Vincent Giampietro Rudolf Uher David Mataix-Cols Michael J Brammer Steven C R Williams Janet Treasure Iain C Campbell Provocation of symmetry/ordering symptoms in Anorexia nervosa: a functional neuroimaging study.
description	Anorexia nervosa (AN), obsessive-compulsive disorder (OCD), and obsessive-compulsive personality disorder (OCPD) are often co-morbid; however, the aetiology of such co-morbidity has not been well investigated. This study examined brain activation in women with AN and in healthy control (HC) women during the provocation of symmetry/ordering-related anxiety. During provocation, patients with AN showed more anxiety compared to HCs, which was correlated with the severity of symmetry/ordering symptoms. Activation in the right parietal lobe and right prefrontal cortex (rPFC) in response to provocation was reduced in the AN group compared with the HC group. The reduced right parietal activation observed in the AN group is consistent with parietal lobe involvement in visuospatial cognition and with studies of OCD reporting an association between structural abnormalities in this region and the severity of 'ordering' symptoms. Reduced rPFC activation in response to symmetry/ordering provocation has similarities with some, but not all, data collected from patients with AN who were exposed to images of food and bodies. Furthermore, the combination of data from the AN and HC groups showed that rPFC activation during symptom provocation was inversely correlated with the severity of symmetry/ordering symptoms. These data suggest that individuals with AN have a diminished ability to cognitively deal with illness-associated symptoms of provocation. Furthermore, our data also suggest that symptom provocation can progressively overload attempts by the rPFC to exert cognitive control. These findings are discussed in the context of the current neurobiological models of AN.
format	article
author	Masashi Suda Samantha J Brooks Vincent Giampietro Rudolf Uher David Mataix-Cols Michael J Brammer Steven C R Williams Janet Treasure Iain C Campbell
author_facet	Masashi Suda Samantha J Brooks Vincent Giampietro Rudolf Uher David Mataix-Cols Michael J Brammer Steven C R Williams Janet Treasure Iain C Campbell
author_sort	Masashi Suda
title	Provocation of symmetry/ordering symptoms in Anorexia nervosa: a functional neuroimaging study.
title_short	Provocation of symmetry/ordering symptoms in Anorexia nervosa: a functional neuroimaging study.
title_full	Provocation of symmetry/ordering symptoms in Anorexia nervosa: a functional neuroimaging study.
title_fullStr	Provocation of symmetry/ordering symptoms in Anorexia nervosa: a functional neuroimaging study.
title_full_unstemmed	Provocation of symmetry/ordering symptoms in Anorexia nervosa: a functional neuroimaging study.
title_sort	provocation of symmetry/ordering symptoms in anorexia nervosa: a functional neuroimaging study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/876b921d948b427bae1d922235a04457
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Provocation of symmetry/ordering symptoms in Anorexia nervosa: a functional neuroimaging study.

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