The association between douching, genital talc use, and the risk of prevalent and incident cervical cancer

Abstract While human papillomavirus is the primary cause of cervical cancer, other factors may influence susceptibility and response to the virus. Candidates include douching and talcum powder applied in the genital area. We used Cox proportional hazards models to estimate confounder-adjusted hazard...

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Autores principales:	Katie M. O’Brien, Clarice R. Weinberg, Aimee A. D’Aloisio, Kristen R. Moore, Dale P. Sandler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/876bacc4d1b34c8985fcf95d7b682c30
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spelling	oai:doaj.org-article:876bacc4d1b34c8985fcf95d7b682c302021-12-02T16:17:21ZThe association between douching, genital talc use, and the risk of prevalent and incident cervical cancer10.1038/s41598-021-94447-32045-2322https://doaj.org/article/876bacc4d1b34c8985fcf95d7b682c302021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94447-3https://doaj.org/toc/2045-2322Abstract While human papillomavirus is the primary cause of cervical cancer, other factors may influence susceptibility and response to the virus. Candidates include douching and talcum powder applied in the genital area. We used Cox proportional hazards models to estimate confounder-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) in the Sister Study (2003–2009), a US cohort of women aged 35–74. We considered pre-baseline (n = 523) and incident (n = 31) cervical cancers. Douching at ages 10–13 was positively associated with pre-baseline cervical cancer (HR 1.32, 95% CI 0.86–2.03), though the association was not statistically significant. We did not observe an association between adolescent talc use and pre-baseline cervical cancer (HR 0.95, 95% CI 0.76–1.19). Douching in the year before enrollment was positively associated with incident cervical cancer (HR 2.56, 95% CI 1.10–5.99). The association between recent genital talc use and incident cervical cancer was positive, but not statistically significant (HR 1.79, 95% CI 0.78–4.11). The observed positive association between douching and incident cervical cancer is consistent with previous retrospective case–control studies. In the first study to examine genital talc use and cervical cancer, we did not see evidence of an association.Katie M. O’BrienClarice R. WeinbergAimee A. D’AloisioKristen R. MooreDale P. SandlerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katie M. O’Brien Clarice R. Weinberg Aimee A. D’Aloisio Kristen R. Moore Dale P. Sandler The association between douching, genital talc use, and the risk of prevalent and incident cervical cancer
description	Abstract While human papillomavirus is the primary cause of cervical cancer, other factors may influence susceptibility and response to the virus. Candidates include douching and talcum powder applied in the genital area. We used Cox proportional hazards models to estimate confounder-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) in the Sister Study (2003–2009), a US cohort of women aged 35–74. We considered pre-baseline (n = 523) and incident (n = 31) cervical cancers. Douching at ages 10–13 was positively associated with pre-baseline cervical cancer (HR 1.32, 95% CI 0.86–2.03), though the association was not statistically significant. We did not observe an association between adolescent talc use and pre-baseline cervical cancer (HR 0.95, 95% CI 0.76–1.19). Douching in the year before enrollment was positively associated with incident cervical cancer (HR 2.56, 95% CI 1.10–5.99). The association between recent genital talc use and incident cervical cancer was positive, but not statistically significant (HR 1.79, 95% CI 0.78–4.11). The observed positive association between douching and incident cervical cancer is consistent with previous retrospective case–control studies. In the first study to examine genital talc use and cervical cancer, we did not see evidence of an association.
format	article
author	Katie M. O’Brien Clarice R. Weinberg Aimee A. D’Aloisio Kristen R. Moore Dale P. Sandler
author_facet	Katie M. O’Brien Clarice R. Weinberg Aimee A. D’Aloisio Kristen R. Moore Dale P. Sandler
author_sort	Katie M. O’Brien
title	The association between douching, genital talc use, and the risk of prevalent and incident cervical cancer
title_short	The association between douching, genital talc use, and the risk of prevalent and incident cervical cancer
title_full	The association between douching, genital talc use, and the risk of prevalent and incident cervical cancer
title_fullStr	The association between douching, genital talc use, and the risk of prevalent and incident cervical cancer
title_full_unstemmed	The association between douching, genital talc use, and the risk of prevalent and incident cervical cancer
title_sort	association between douching, genital talc use, and the risk of prevalent and incident cervical cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/876bacc4d1b34c8985fcf95d7b682c30
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The association between douching, genital talc use, and the risk of prevalent and incident cervical cancer

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