Immunoinflammatory Profile in Patients with Episodic and Continuous Paranoid Schizophrenia

Introduction. Associations of disturbances in innate and adaptive immunity during the clinical course of schizophrenia have been found in a number of studies. Yet, the relationship of immune parameters and systemic inflammation in relation to the clinical course of the disease and its prognosis, rem...

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Autores principales:	Irina K. Malashenkova, Sergey A. Krynskiy, Daniil P. Ogurtsov, Nikita A. Hailov, Natalia V. Zakharova, Lidia V. Bravve, Maria A. Kaydan, Ekaterina I. Chekulaeva, Denis S. Andreyuk, Vadim L. Ushakov, Nikolay A. Didkovsky, Georgy P. Kostyuk
Formato:	article
Lenguaje:	EN RU
Publicado:	Eco-Vector 2021
Materias:	adaptive immunity cytokines inflammation innate immunity schizophrenia Psychiatry RC435-571 Psychology BF1-990
Acceso en línea:	https://doaj.org/article/876bbb76624044ae813684d922e3bfb4
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spelling	oai:doaj.org-article:876bbb76624044ae813684d922e3bfb42021-11-30T16:05:53ZImmunoinflammatory Profile in Patients with Episodic and Continuous Paranoid Schizophrenia2712-76722713-291910.17816/CP66https://doaj.org/article/876bbb76624044ae813684d922e3bfb42021-03-01T00:00:00Zhttps://consortium-psy.com/jour/article/viewFile/66/33https://doaj.org/toc/2712-7672https://doaj.org/toc/2713-2919Introduction. Associations of disturbances in innate and adaptive immunity during the clinical course of schizophrenia have been found in a number of studies. Yet, the relationship of immune parameters and systemic inflammation in relation to the clinical course of the disease and its prognosis, remains poorly understood, which highlights an interesting topic for further research. The goal of this study was to research the immuno-inflammatory changes in patients with clinical continuous and episodic paranoid schizophrenia, to assess the pathogenetic significance of these changes. Methods. Thirty-six patients with paranoid schizophrenia, of which 20 had episodic symptoms and 16 had continuous symptoms, consented to participate in the study, together with 30 healthy volunteers. In the study we assessed the parameters of innate immune response (serum levels of key pro-inflammatory and anti-inflammatory cytokines, C-reactive protein) and the adaptive immune response, including humoral-mediated immunity (serum immunoglobulins IgA, IgM, IgG, circulating immune complexes), as well as the cell link of adaptive immunity (key lymphocyte subpopulations). Positive and negative symptoms were assessed with the positive and negative symptoms scale; frontal dysfunction was assessed by Frontal Assessment Battery (FAB). Results. Both patient groups had higher than normal levels of C-reactive protein and IL-8. There was a significant elevation of circulating immune complexes among patients with continuous symptoms of schizophrenia, compared to patients with episodic symptoms and healthy controls. Levels of CD45+CD3+ lymphocytes (T-cells) differed between clinical groups, with higher values identified among patients with episodic symptoms and lower values among those with continuous symptoms. In addition, patients with episodic symptoms had significantly increased levels of CD45+CD3+CD4+CD25+CD127- regulatory T-cells. Finally, the level of CD45+CD3-CD19+ B-cells was significantly higher among patients with continuous symptoms vs. patients with episodic symptoms and the control groups. Markers of activation of humoral immunity were associated with the severity of frontal disorders in these patients. Discussion. Comprehensive data on the serum level of cytokines and the parameters of adaptive immunity among individuals with continuous schizophrenia, by comparison with patients with episodic schizophrenia, are practically absent in the literature. We have shown that among those with continuous schizophrenia, there are signs of systemic inflammation and chronic activation of the adaptive humoral immune response, while among patients with episodic symptoms of the disease, there are signs of systemic inflammation and certain activation of cell-mediated immunity, without significant changes in the humoral link of adaptive immunity. Conclusion. More studies are needed, but the data obtained in this study are important for subsequent clinical studies of new treatment methods, based on various immunophenotypes of schizophrenia.Irina K. MalashenkovaSergey A. KrynskiyDaniil P. OgurtsovNikita A. HailovNatalia V. ZakharovaLidia V. BravveMaria A. KaydanEkaterina I. ChekulaevaDenis S. AndreyukVadim L. UshakovNikolay A. DidkovskyGeorgy P. KostyukEco-Vectorarticleadaptive immunitycytokinesinflammationinnate immunityschizophreniaPsychiatryRC435-571PsychologyBF1-990ENRUConsortium Psychiatricum, Vol 2, Iss 1, Pp 19-31 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	adaptive immunity cytokines inflammation innate immunity schizophrenia Psychiatry RC435-571 Psychology BF1-990
spellingShingle	adaptive immunity cytokines inflammation innate immunity schizophrenia Psychiatry RC435-571 Psychology BF1-990 Irina K. Malashenkova Sergey A. Krynskiy Daniil P. Ogurtsov Nikita A. Hailov Natalia V. Zakharova Lidia V. Bravve Maria A. Kaydan Ekaterina I. Chekulaeva Denis S. Andreyuk Vadim L. Ushakov Nikolay A. Didkovsky Georgy P. Kostyuk Immunoinflammatory Profile in Patients with Episodic and Continuous Paranoid Schizophrenia
description	Introduction. Associations of disturbances in innate and adaptive immunity during the clinical course of schizophrenia have been found in a number of studies. Yet, the relationship of immune parameters and systemic inflammation in relation to the clinical course of the disease and its prognosis, remains poorly understood, which highlights an interesting topic for further research. The goal of this study was to research the immuno-inflammatory changes in patients with clinical continuous and episodic paranoid schizophrenia, to assess the pathogenetic significance of these changes. Methods. Thirty-six patients with paranoid schizophrenia, of which 20 had episodic symptoms and 16 had continuous symptoms, consented to participate in the study, together with 30 healthy volunteers. In the study we assessed the parameters of innate immune response (serum levels of key pro-inflammatory and anti-inflammatory cytokines, C-reactive protein) and the adaptive immune response, including humoral-mediated immunity (serum immunoglobulins IgA, IgM, IgG, circulating immune complexes), as well as the cell link of adaptive immunity (key lymphocyte subpopulations). Positive and negative symptoms were assessed with the positive and negative symptoms scale; frontal dysfunction was assessed by Frontal Assessment Battery (FAB). Results. Both patient groups had higher than normal levels of C-reactive protein and IL-8. There was a significant elevation of circulating immune complexes among patients with continuous symptoms of schizophrenia, compared to patients with episodic symptoms and healthy controls. Levels of CD45+CD3+ lymphocytes (T-cells) differed between clinical groups, with higher values identified among patients with episodic symptoms and lower values among those with continuous symptoms. In addition, patients with episodic symptoms had significantly increased levels of CD45+CD3+CD4+CD25+CD127- regulatory T-cells. Finally, the level of CD45+CD3-CD19+ B-cells was significantly higher among patients with continuous symptoms vs. patients with episodic symptoms and the control groups. Markers of activation of humoral immunity were associated with the severity of frontal disorders in these patients. Discussion. Comprehensive data on the serum level of cytokines and the parameters of adaptive immunity among individuals with continuous schizophrenia, by comparison with patients with episodic schizophrenia, are practically absent in the literature. We have shown that among those with continuous schizophrenia, there are signs of systemic inflammation and chronic activation of the adaptive humoral immune response, while among patients with episodic symptoms of the disease, there are signs of systemic inflammation and certain activation of cell-mediated immunity, without significant changes in the humoral link of adaptive immunity. Conclusion. More studies are needed, but the data obtained in this study are important for subsequent clinical studies of new treatment methods, based on various immunophenotypes of schizophrenia.
format	article
author	Irina K. Malashenkova Sergey A. Krynskiy Daniil P. Ogurtsov Nikita A. Hailov Natalia V. Zakharova Lidia V. Bravve Maria A. Kaydan Ekaterina I. Chekulaeva Denis S. Andreyuk Vadim L. Ushakov Nikolay A. Didkovsky Georgy P. Kostyuk
author_facet	Irina K. Malashenkova Sergey A. Krynskiy Daniil P. Ogurtsov Nikita A. Hailov Natalia V. Zakharova Lidia V. Bravve Maria A. Kaydan Ekaterina I. Chekulaeva Denis S. Andreyuk Vadim L. Ushakov Nikolay A. Didkovsky Georgy P. Kostyuk
author_sort	Irina K. Malashenkova
title	Immunoinflammatory Profile in Patients with Episodic and Continuous Paranoid Schizophrenia
title_short	Immunoinflammatory Profile in Patients with Episodic and Continuous Paranoid Schizophrenia
title_full	Immunoinflammatory Profile in Patients with Episodic and Continuous Paranoid Schizophrenia
title_fullStr	Immunoinflammatory Profile in Patients with Episodic and Continuous Paranoid Schizophrenia
title_full_unstemmed	Immunoinflammatory Profile in Patients with Episodic and Continuous Paranoid Schizophrenia
title_sort	immunoinflammatory profile in patients with episodic and continuous paranoid schizophrenia
publisher	Eco-Vector
publishDate	2021
url	https://doaj.org/article/876bbb76624044ae813684d922e3bfb4
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Immunoinflammatory Profile in Patients with Episodic and Continuous Paranoid Schizophrenia

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