Disordered binding regions and linear motifs--bridging the gap between two models of molecular recognition.

Intrinsically disordered proteins (IDPs) exist without the presence of a stable tertiary structure in isolation. These proteins are often involved in molecular recognition processes via their disordered binding regions that can recognize partner molecules by undergoing a coupled folding and binding...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bálint Mészáros, Zsuzsanna Dosztányi, István Simon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/876c8045480c4bb59ff80de9245bd862
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:876c8045480c4bb59ff80de9245bd862
record_format	dspace
spelling	oai:doaj.org-article:876c8045480c4bb59ff80de9245bd8622021-11-18T08:13:17ZDisordered binding regions and linear motifs--bridging the gap between two models of molecular recognition.1932-620310.1371/journal.pone.0046829https://doaj.org/article/876c8045480c4bb59ff80de9245bd8622012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23056474/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Intrinsically disordered proteins (IDPs) exist without the presence of a stable tertiary structure in isolation. These proteins are often involved in molecular recognition processes via their disordered binding regions that can recognize partner molecules by undergoing a coupled folding and binding process. The specific properties of disordered binding regions give way to specific, yet transient interactions that enable IDPs to play central roles in signaling pathways and act as hubs of protein interaction networks. An alternative model of protein-protein interactions with largely overlapping functional properties is offered by the concept of linear interaction motifs. This approach focuses on distilling a short consensus sequence pattern from proteins with a common interaction partner. These motifs often reside in disordered regions and are considered to mediate the interaction roughly independent from the rest of the protein. Although a connection between linear motifs and disordered binding regions has been established through common examples, the complementary nature of the two concepts has yet to be fully explored. In many cases the sequence based definition of linear motifs and the structural context based definition of disordered binding regions describe two aspects of the same phenomenon. To gain insight into the connection between the two models, prediction methods were utilized. We combined the regular expression based prediction of linear motifs with the disordered binding region prediction method ANCHOR, each specialized for either model to get the best of both worlds. The thorough analysis of the overlap of the two methods offers a bioinformatics tool for more efficient binding site prediction that can serve a wide range of practical implications. At the same time it can also shed light on the theoretical connection between the two co-existing interaction models.Bálint MészárosZsuzsanna DosztányiIstván SimonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e46829 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bálint Mészáros Zsuzsanna Dosztányi István Simon Disordered binding regions and linear motifs--bridging the gap between two models of molecular recognition.
description	Intrinsically disordered proteins (IDPs) exist without the presence of a stable tertiary structure in isolation. These proteins are often involved in molecular recognition processes via their disordered binding regions that can recognize partner molecules by undergoing a coupled folding and binding process. The specific properties of disordered binding regions give way to specific, yet transient interactions that enable IDPs to play central roles in signaling pathways and act as hubs of protein interaction networks. An alternative model of protein-protein interactions with largely overlapping functional properties is offered by the concept of linear interaction motifs. This approach focuses on distilling a short consensus sequence pattern from proteins with a common interaction partner. These motifs often reside in disordered regions and are considered to mediate the interaction roughly independent from the rest of the protein. Although a connection between linear motifs and disordered binding regions has been established through common examples, the complementary nature of the two concepts has yet to be fully explored. In many cases the sequence based definition of linear motifs and the structural context based definition of disordered binding regions describe two aspects of the same phenomenon. To gain insight into the connection between the two models, prediction methods were utilized. We combined the regular expression based prediction of linear motifs with the disordered binding region prediction method ANCHOR, each specialized for either model to get the best of both worlds. The thorough analysis of the overlap of the two methods offers a bioinformatics tool for more efficient binding site prediction that can serve a wide range of practical implications. At the same time it can also shed light on the theoretical connection between the two co-existing interaction models.
format	article
author	Bálint Mészáros Zsuzsanna Dosztányi István Simon
author_facet	Bálint Mészáros Zsuzsanna Dosztányi István Simon
author_sort	Bálint Mészáros
title	Disordered binding regions and linear motifs--bridging the gap between two models of molecular recognition.
title_short	Disordered binding regions and linear motifs--bridging the gap between two models of molecular recognition.
title_full	Disordered binding regions and linear motifs--bridging the gap between two models of molecular recognition.
title_fullStr	Disordered binding regions and linear motifs--bridging the gap between two models of molecular recognition.
title_full_unstemmed	Disordered binding regions and linear motifs--bridging the gap between two models of molecular recognition.
title_sort	disordered binding regions and linear motifs--bridging the gap between two models of molecular recognition.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/876c8045480c4bb59ff80de9245bd862
work_keys_str_mv	AT balintmeszaros disorderedbindingregionsandlinearmotifsbridgingthegapbetweentwomodelsofmolecularrecognition AT zsuzsannadosztanyi disorderedbindingregionsandlinearmotifsbridgingthegapbetweentwomodelsofmolecularrecognition AT istvansimon disorderedbindingregionsandlinearmotifsbridgingthegapbetweentwomodelsofmolecularrecognition
_version_	1718422054046269440

Disordered binding regions and linear motifs--bridging the gap between two models of molecular recognition.

Ejemplares similares