Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models

Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models

Summary: Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by reduced survival motor neuron (SMN) protein. Recently, SMN dysfunction has been linked to individual aspects of motor circuit pathology in a severe SMA mouse model. To determine whether these disease mechanisms are conse...

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Bibliographic Details
Main Authors: Jannik M. Buettner, Josiane K. Sime Longang, Florian Gerstner, Katharina S. Apel, Beatriz Blanco-Redondo, Leonie Sowoidnich, Eva Janzen, Tobias Langenhan, Brunhilde Wirth, Christian M. Simon
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
Molecular biology
Neuroscience
Molecular neuroscience
Science
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Online Access:https://doaj.org/article/876d4240d23740fc9dadab41c2948ab4
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https://doaj.org/article/876d4240d23740fc9dadab41c2948ab4

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