Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development

Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development

De novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin3 (CUL3) lead to autism spectrum disorder (ASD). Here, the authors show that Cul3 is essential to regulate neuronal migration by tightly regulating Plastin3 (Pls3). Pls3 cell-autonomously regulates cell migration by regul...

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Autores principales: Jasmin Morandell, Lena A. Schwarz, Bernadette Basilico, Saren Tasciyan, Georgi Dimchev, Armel Nicolas, Christoph Sommer, Caroline Kreuzinger, Christoph P. Dotter, Lisa S. Knaus, Zoe Dobler, Emanuele Cacci, Florian K. M. Schur, Johann G. Danzl, Gaia Novarino
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/876fc6b3ec944da69828b7d04ddbbfcd
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spelling oai:doaj.org-article:876fc6b3ec944da69828b7d04ddbbfcd2021-12-02T15:00:58ZCul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development10.1038/s41467-021-23123-x2041-1723https://doaj.org/article/876fc6b3ec944da69828b7d04ddbbfcd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23123-xhttps://doaj.org/toc/2041-1723De novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin3 (CUL3) lead to autism spectrum disorder (ASD). Here, the authors show that Cul3 is essential to regulate neuronal migration by tightly regulating Plastin3 (Pls3). Pls3 cell-autonomously regulates cell migration by regulating the actin cytoskeleton organization.Jasmin MorandellLena A. SchwarzBernadette BasilicoSaren TasciyanGeorgi DimchevArmel NicolasChristoph SommerCaroline KreuzingerChristoph P. DotterLisa S. KnausZoe DoblerEmanuele CacciFlorian K. M. SchurJohann G. DanzlGaia NovarinoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jasmin Morandell
Lena A. Schwarz
Bernadette Basilico
Saren Tasciyan
Georgi Dimchev
Armel Nicolas
Christoph Sommer
Caroline Kreuzinger
Christoph P. Dotter
Lisa S. Knaus
Zoe Dobler
Emanuele Cacci
Florian K. M. Schur
Johann G. Danzl
Gaia Novarino
Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development
description De novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin3 (CUL3) lead to autism spectrum disorder (ASD). Here, the authors show that Cul3 is essential to regulate neuronal migration by tightly regulating Plastin3 (Pls3). Pls3 cell-autonomously regulates cell migration by regulating the actin cytoskeleton organization.
format article
author Jasmin Morandell
Lena A. Schwarz
Bernadette Basilico
Saren Tasciyan
Georgi Dimchev
Armel Nicolas
Christoph Sommer
Caroline Kreuzinger
Christoph P. Dotter
Lisa S. Knaus
Zoe Dobler
Emanuele Cacci
Florian K. M. Schur
Johann G. Danzl
Gaia Novarino
author_facet Jasmin Morandell
Lena A. Schwarz
Bernadette Basilico
Saren Tasciyan
Georgi Dimchev
Armel Nicolas
Christoph Sommer
Caroline Kreuzinger
Christoph P. Dotter
Lisa S. Knaus
Zoe Dobler
Emanuele Cacci
Florian K. M. Schur
Johann G. Danzl
Gaia Novarino
author_sort Jasmin Morandell
title Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development
title_short Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development
title_full Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development
title_fullStr Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development
title_full_unstemmed Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development
title_sort cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/876fc6b3ec944da69828b7d04ddbbfcd
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