LNK suppresses interferon signaling in melanoma

LNK is a tumor suppressor in hematopoietic cancers, but its function in melanoma is unclear. Here, the authors show that the overexpression of LNK in melanomas correlate with hyperactive signaling of the RAS-RAF-MEK pathway and LNK enhances melanoma growth and survival and immune evasion by inhibiti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ling-Wen Ding, Qiao-Yang Sun, Jarem J. Edwards, Lucia Torres Fernández, Xue-Bin Ran, Si-Qin Zhou, Richard A. Scolyer, James S. Wilmott, John F. Thompson, Ngan Doan, Jonathan W. Said, Nachiyappan Venkatachalam, Jin-Fen Xiao, Xin-Yi Loh, Maren Pein, Liang Xu, David W. Mullins, Henry Yang, De-Chen Lin, H. Phillip Koeffler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/87746954caf641c38aaf967ff326924d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:87746954caf641c38aaf967ff326924d
record_format	dspace
spelling	oai:doaj.org-article:87746954caf641c38aaf967ff326924d2021-12-02T14:40:20ZLNK suppresses interferon signaling in melanoma10.1038/s41467-019-09711-y2041-1723https://doaj.org/article/87746954caf641c38aaf967ff326924d2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09711-yhttps://doaj.org/toc/2041-1723LNK is a tumor suppressor in hematopoietic cancers, but its function in melanoma is unclear. Here, the authors show that the overexpression of LNK in melanomas correlate with hyperactive signaling of the RAS-RAF-MEK pathway and LNK enhances melanoma growth and survival and immune evasion by inhibiting IFN signalling.Ling-Wen DingQiao-Yang SunJarem J. EdwardsLucia Torres FernándezXue-Bin RanSi-Qin ZhouRichard A. ScolyerJames S. WilmottJohn F. ThompsonNgan DoanJonathan W. SaidNachiyappan VenkatachalamJin-Fen XiaoXin-Yi LohMaren PeinLiang XuDavid W. MullinsHenry YangDe-Chen LinH. Phillip KoefflerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ling-Wen Ding Qiao-Yang Sun Jarem J. Edwards Lucia Torres Fernández Xue-Bin Ran Si-Qin Zhou Richard A. Scolyer James S. Wilmott John F. Thompson Ngan Doan Jonathan W. Said Nachiyappan Venkatachalam Jin-Fen Xiao Xin-Yi Loh Maren Pein Liang Xu David W. Mullins Henry Yang De-Chen Lin H. Phillip Koeffler LNK suppresses interferon signaling in melanoma
description	LNK is a tumor suppressor in hematopoietic cancers, but its function in melanoma is unclear. Here, the authors show that the overexpression of LNK in melanomas correlate with hyperactive signaling of the RAS-RAF-MEK pathway and LNK enhances melanoma growth and survival and immune evasion by inhibiting IFN signalling.
format	article
author	Ling-Wen Ding Qiao-Yang Sun Jarem J. Edwards Lucia Torres Fernández Xue-Bin Ran Si-Qin Zhou Richard A. Scolyer James S. Wilmott John F. Thompson Ngan Doan Jonathan W. Said Nachiyappan Venkatachalam Jin-Fen Xiao Xin-Yi Loh Maren Pein Liang Xu David W. Mullins Henry Yang De-Chen Lin H. Phillip Koeffler
author_facet	Ling-Wen Ding Qiao-Yang Sun Jarem J. Edwards Lucia Torres Fernández Xue-Bin Ran Si-Qin Zhou Richard A. Scolyer James S. Wilmott John F. Thompson Ngan Doan Jonathan W. Said Nachiyappan Venkatachalam Jin-Fen Xiao Xin-Yi Loh Maren Pein Liang Xu David W. Mullins Henry Yang De-Chen Lin H. Phillip Koeffler
author_sort	Ling-Wen Ding
title	LNK suppresses interferon signaling in melanoma
title_short	LNK suppresses interferon signaling in melanoma
title_full	LNK suppresses interferon signaling in melanoma
title_fullStr	LNK suppresses interferon signaling in melanoma
title_full_unstemmed	LNK suppresses interferon signaling in melanoma
title_sort	lnk suppresses interferon signaling in melanoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/87746954caf641c38aaf967ff326924d
work_keys_str_mv	AT lingwending lnksuppressesinterferonsignalinginmelanoma AT qiaoyangsun lnksuppressesinterferonsignalinginmelanoma AT jaremjedwards lnksuppressesinterferonsignalinginmelanoma AT luciatorresfernandez lnksuppressesinterferonsignalinginmelanoma AT xuebinran lnksuppressesinterferonsignalinginmelanoma AT siqinzhou lnksuppressesinterferonsignalinginmelanoma AT richardascolyer lnksuppressesinterferonsignalinginmelanoma AT jamesswilmott lnksuppressesinterferonsignalinginmelanoma AT johnfthompson lnksuppressesinterferonsignalinginmelanoma AT ngandoan lnksuppressesinterferonsignalinginmelanoma AT jonathanwsaid lnksuppressesinterferonsignalinginmelanoma AT nachiyappanvenkatachalam lnksuppressesinterferonsignalinginmelanoma AT jinfenxiao lnksuppressesinterferonsignalinginmelanoma AT xinyiloh lnksuppressesinterferonsignalinginmelanoma AT marenpein lnksuppressesinterferonsignalinginmelanoma AT liangxu lnksuppressesinterferonsignalinginmelanoma AT davidwmullins lnksuppressesinterferonsignalinginmelanoma AT henryyang lnksuppressesinterferonsignalinginmelanoma AT dechenlin lnksuppressesinterferonsignalinginmelanoma AT hphillipkoeffler lnksuppressesinterferonsignalinginmelanoma
_version_	1718390307809132544

LNK suppresses interferon signaling in melanoma

Ejemplares similares