Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation

Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation

Nonsense-mediated mRNA decay (NMD) is a translation-coupled process that eliminates mRNAs containing premature translation-termination codons. Here the authors identify a role for the NMD factor UPF1 in protein quality control, whereby truncated misfolded polypeptides are cleared through autophagy.

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Autores principales: Yeonkyoung Park, Joori Park, Hyun Jung Hwang, Byungju Kim, Kwon Jeong, Jeeyoon Chang, Jong-Bong Lee, Yoon Ki Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/877497130d0f4624acd427291cc0d0a5
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spelling oai:doaj.org-article:877497130d0f4624acd427291cc0d0a52021-12-02T17:40:00ZNonsense-mediated mRNA decay factor UPF1 promotes aggresome formation10.1038/s41467-020-16939-62041-1723https://doaj.org/article/877497130d0f4624acd427291cc0d0a52020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16939-6https://doaj.org/toc/2041-1723Nonsense-mediated mRNA decay (NMD) is a translation-coupled process that eliminates mRNAs containing premature translation-termination codons. Here the authors identify a role for the NMD factor UPF1 in protein quality control, whereby truncated misfolded polypeptides are cleared through autophagy.Yeonkyoung ParkJoori ParkHyun Jung HwangByungju KimKwon JeongJeeyoon ChangJong-Bong LeeYoon Ki KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yeonkyoung Park
Joori Park
Hyun Jung Hwang
Byungju Kim
Kwon Jeong
Jeeyoon Chang
Jong-Bong Lee
Yoon Ki Kim
Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation
description Nonsense-mediated mRNA decay (NMD) is a translation-coupled process that eliminates mRNAs containing premature translation-termination codons. Here the authors identify a role for the NMD factor UPF1 in protein quality control, whereby truncated misfolded polypeptides are cleared through autophagy.
format article
author Yeonkyoung Park
Joori Park
Hyun Jung Hwang
Byungju Kim
Kwon Jeong
Jeeyoon Chang
Jong-Bong Lee
Yoon Ki Kim
author_facet Yeonkyoung Park
Joori Park
Hyun Jung Hwang
Byungju Kim
Kwon Jeong
Jeeyoon Chang
Jong-Bong Lee
Yoon Ki Kim
author_sort Yeonkyoung Park
title Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation
title_short Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation
title_full Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation
title_fullStr Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation
title_full_unstemmed Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation
title_sort nonsense-mediated mrna decay factor upf1 promotes aggresome formation
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/877497130d0f4624acd427291cc0d0a5
work_keys_str_mv AT yeonkyoungpark nonsensemediatedmrnadecayfactorupf1promotesaggresomeformation
AT jooripark nonsensemediatedmrnadecayfactorupf1promotesaggresomeformation
AT hyunjunghwang nonsensemediatedmrnadecayfactorupf1promotesaggresomeformation
AT byungjukim nonsensemediatedmrnadecayfactorupf1promotesaggresomeformation
AT kwonjeong nonsensemediatedmrnadecayfactorupf1promotesaggresomeformation
AT jeeyoonchang nonsensemediatedmrnadecayfactorupf1promotesaggresomeformation
AT jongbonglee nonsensemediatedmrnadecayfactorupf1promotesaggresomeformation
AT yoonkikim nonsensemediatedmrnadecayfactorupf1promotesaggresomeformation
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